Abstract
We report on a case of a 17-year-old female with systemic lupus erythematosus (SLE), with a clinical history of complex partial seizure, who developed a tonicoclonic crisis after receiving hydroxychloroquine for 2 weeks at a dosage of 200 mg/day (5 mg/kg). The absence of previous similar episodes and of recurrences after withdrawal of the drug in subsequent months, the short latency after administration and the favourable short-term evolution raised suspicions for a potential role of the drug in the development of the isolated convulsive crisis. It is possible for hydroxychloroquine to be responsible for tonicoclonic seizures in predisposed subjects.
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Received: 19 March 2000 / Accepted: 16 June 2000
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Malcangi, G., Fraticelli, P., Palmieri, C. et al. Hydroxychloroquine-induced seizure in a patient with systemic lupus erythematosus. Rheumatology International 20, 31–33 (2000). https://doi.org/10.1007/s002960000066
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DOI: https://doi.org/10.1007/s002960000066