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Are fatty acids associated with disease activity and biomarkers in patients with psoriatic arthritis? Data from a multicenter clinical trial

  • Observational Research
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Abstract

The pathogenesis of psoriatic arthritis (PsA) involves inflammation and bone and soft tissue turnover. Dietary fatty acids have previously been associated with pro-inflammatory effects induced by saturated fatty acids (SFA) and anti-inflammatory effects achieved by at least some polyunsaturated fatty acids (PUFA). The aim of the study was to investigate the correlations between the content of fatty acids in granulocytes and clinical and biochemical markers of PsA. A total of 140 patients with PsA were included. Skin and joint disease activity were assessed. Fatty acid composition in granulocytes was determined by gas chromatography. Competitive enzyme-linked immunosorbent assays were used to assess bone and soft tissue turnover. The content of SFA, n-6 PUFA or n-3 PUFA in granulocytes was not associated with disease activity. Marine n-3 PUFA was significantly positively correlated with collagen degradation. In contrast, n-6 PUFA was significantly positively correlated with collagen formation and negatively correlated with collagen degradation. However, the correlations were all weak. No association was found between the content of fatty acids in granulocytes and disease activity in this population of patients with PsA. The correlation between fatty acids and biomarkers of bone and soft tissue turnover needs further investigation.

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Funding

This work was supported by the Danish Research Foundation “Den Danske Forskningsfond”, the Innovation Fund Denmark (Innovationsfonden), the Danish Rheumatism Association and the Danish Psoriasis Foundation.

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Authors and Affiliations

  1. Department of Rheumatology, Aalborg University Hospital, Aalborg, Denmark

    Salome Kristensen

  2. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark

    Salome Kristensen, Erik Berg Schmidt & Jeppe Hagstrup Christensen

  3. ImmunoScience, Nordic Bioscience, Herlev, Denmark

    Signe Holm Nielsen, Anne Christine Bay-Jensen & Morten A. Karsdal

  4. Department of Biomedicine and Biotechnology, Technical University of Denmark, Lyngby, Denmark

    Signe Holm Nielsen

  5. Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark

    Erik Berg Schmidt

  6. Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark

    Jeppe Hagstrup Christensen

Authors
  1. Salome Kristensen
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  2. Signe Holm Nielsen
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  3. Erik Berg Schmidt
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  4. Anne Christine Bay-Jensen
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  6. Jeppe Hagstrup Christensen
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Contributions

Concept and design: All authors. Conduction of the trial: SK. Fatty acid analysis SK and EBS. Biomarker analysis: SHN and ACBJ. Drafting of the manuscript: SK. Statistical analysis: SK and SHN. Critical revision of the manuscript for important intellectual content: All authors. Supervision: EBS, JHC, MAK, ACBJ.

Corresponding author

Correspondence to Salome Kristensen.

Ethics declarations

SHN, ACBJ and MAK are full-time employee at Nordic Bioscience A/S. Nordic Bioscience is a privately owned, small–medium size enterprise (SME) partly focused on the development of biomarkers. MAK holds stocks in Nordic Bioscience A/S. None of the authors received fees, bonuses or other benefits for the work described in the manuscript.

Ethical approval

All participants gave their oral and written informed consent and the regional ethics committee of North Denmark approved the study (reference number N20120076). The study was approved by the Danish Data Protection Agency (2008-58-0028) and registered at ClinicalTrials.gov (NCT01818804). The study was conducted in accordance with the Declaration of Helsinki.

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Kristensen, S., Nielsen, S.H., Schmidt, E.B. et al. Are fatty acids associated with disease activity and biomarkers in patients with psoriatic arthritis? Data from a multicenter clinical trial. Rheumatol Int 42, 1009–1014 (2022). https://doi.org/10.1007/s00296-021-04953-w

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  • DOI: https://doi.org/10.1007/s00296-021-04953-w

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