A prospective study of novel disease activity indices for ankylosing spondylitis

Abstract

There is an ongoing quest for robust disease activity measures in Ankylosing spondylitis (AS). Thus, we prospectively validated two new disease activity indices, Simplified AS Disease Activity Score (SASDAS) and modified Juvenile Spondyloarthritis Disease Activity Score (JSpADA). Patients with AS were assessed for BASDAI, ASDAS and other outcome measures at baseline and 3 months. Comparisons were drawn between those with juvenile onset, early disease and peripheral involvement, with the rest. Fisher’s r to Z transformation was used to compare correlations. Receiver-operating characteristic (ROC) curves were used to calculate cutoffs for inactive, low, high and very high disease activity. Of the 107 patients (mean age—29 years) of 6-years long disease, 38.3% had a juvenile onset. SASDAS and modified JSpADA exhibited excellent correlation with BASDAI and ASDAS (all p < 0.001) and were higher in active vs. inactive disease. Treatment responders had a greater fall in SASDAS and modified JSpADA as compared to non-responders. The novel scores were higher in those with peripheral disease. Only SASDAS could discriminate early from late disease. Based on the previously proposed cutoffs, optimal scores for inactive, moderate, high and very high disease activity were deduced. SASDAS-CRP showed better internal consistency than SASDAS-ESR and correlated better with ASDAS-CRP in late disease (Z = 3.04; p = 002) and those with adult onset disease (Z = 2.18; p = 0.03). SASDAS and Modified JSpADA perform as well as standard complex scores and have potential for simpler daily use. From our analyses, SASDAS with CRP performs better than SASDAS-ESR, pending further validation.

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Funding

This study was not funded.

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Contributions

LG was involved in ideation, data collection, analysis and manuscript preparation. STG was involved in data analysis and manuscript preparation. HM was involved in data analysis. All authors critically reviewed the manuscript for intelligent inputs. All co-authors have read the final version, approve it and take full responsibility for the integrity of the study and the final manuscript has already been mentioned in the title file.

Corresponding author

Correspondence to Latika Gupta.

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The authors declare that there is no conflict of interest.

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Due ethics permissions were obtained from the institute ethics committee of SGPGIMS, Lucknow as per local guidelines.

Data sharing statement

All the data pertaining to the study are included in the manuscript and as supplementary material. Previously data presented as a poster at the Indian Rheumatology Association Conference 2019: T G Sundaram (2019). Validation of simplified disease activity score for ankylosing spondylitis. PC0160. IRACON. Indian Journal of Rheumatology.2019: 14 (6)Supplement. S196.

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Sundaram, T.G., Muhammed, H., Aggarwal, A. et al. A prospective study of novel disease activity indices for ankylosing spondylitis. Rheumatol Int 40, 1843–1849 (2020). https://doi.org/10.1007/s00296-020-04662-w

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Keywords

  • Disease activity indices
  • Ankylosing spondylitis