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Burn center admissions of patients with autoimmune rheumatic diseases: clinical characteristics and outcomes

  • Observational Research
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Abstract

The ojective of this study was to describe the reasons for admission to the burn center of patients with autoimmune rheumatic diseases (ARD), identify their clinical characteristics, and assess their outcomes relative to the non-ARD patients. We conducted a retrospective study of ARD patients admitted to a burn center from 2011 to 2018, and they were compared with a non-ARD group of patients. Medical records were reviewed for patients’ clinical characteristics, including demographics, ARD diagnosis, laboratory studies, and APACHE II score. Additionally, we evaluate the reason for admission in the burn center, management during the burn center stay, complications, outcomes including length of stay, and mortality during the hospital stay. Among the 1094 adult patients admitted during the study period, 30 (2.7%) had a new or prior diagnosis of ARD. The most common ARD associated with admission in the burn center was rheumatoid arthritis (RA) (37%, n = 11) followed by systemic lupus erythematosus (SLE) (33%, n = 10). Burn injuries (47%, n = 14), and Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) (30%, n = 9) were the most frequent admission reasons. Compared with the non-ARD group (n = 52), ARD patients were more likely to be females (60% vs. 24%, P = 0.004), to receive glucocorticoids (50% vs. 6.9%; P < 0.05), require renal replacement (20% vs. 5%, P < 0.05) and enteral nutrition (63% vs. 24%; P < 0.05) during their burn stay. The non-ARD group was more likely to be admitted for burn injuries (81% vs 46%, P < 0.01). RA and SLE were the most common ARD, and burn injuries, followed by SJS/TEN, the most frequent causes associated with burn admissions. ARD patients were more likely to be female, received glucocorticoids, require renal replacement, and enteral nutrition during the burn stay.

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Funding

No specific funding was received from any bodies in the public, commercial or not-for-profit sectors to carry out the work described in this manuscript.

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Authors and Affiliations

  1. Department of Medicine, Medical School, University of Cyprus, University of Arizona College of Medicine, 475 N 5th Street, Phoenix, AZ, USA

    Konstantinos Parperis

  2. Valleywise Health, Biostatistician, University of Arizona College of Medicine, Phoenix, AZ, USA

    Bikash Bhattarai

  3. Department of Medicine, Valleywise Health, Phoenix, AZ, USA

    Mohanad Hadi, Sawjanya Malla, Gauri Barlingay & Monica Ramakuri

  4. Department of Surgery, Valleywise Health, Phoenix, AZ, USA

    Kevin Foster

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  1. Konstantinos Parperis
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  2. Bikash Bhattarai
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  3. Mohanad Hadi
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  4. Sawjanya Malla
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  6. Monica Ramakuri
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  7. Kevin Foster
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Contributions

Study concept and design: KP, BB, KF. All the authors contributed to the data acquisition, analysis and interpretation. All the authors contribute to draft, critically review and revise the manuscript and approve the final version of the manuscript to be published. All co-authors take full responsibility for the integrity of the review.

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Correspondence to Konstantinos Parperis.

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The authors have declared no conflicts of interest.

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Ethics approval

The institutional board review of the Maricopa Integrated Health System (currently Valleywise Health) approved the study on 28/07/2018, approval number is 2018-066, according to the provisions of the Declaration of Helsinki, and due to the retrospective nature of our study, no informed consent was obtained.

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Due to the retrospective nature of our study, no informed consent was obtained.

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Parperis, K., Bhattarai, B., Hadi, M. et al. Burn center admissions of patients with autoimmune rheumatic diseases: clinical characteristics and outcomes. Rheumatol Int 40, 1649–1656 (2020). https://doi.org/10.1007/s00296-020-04617-1

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  • DOI: https://doi.org/10.1007/s00296-020-04617-1

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