Gout is associated with elevated risk of erectile dysfunction: a systematic review and meta-analysis

  • Lianmin Luo
  • Qian Xiang
  • Yihan Deng
  • Shankun Zhao
  • Zhiguo Zhu
  • Yangzhou Liu
  • Jiamin Wang
  • Zhigang ZhaoEmail author
Systematic Review


Previous studies investigating the risk of erectile dysfunction (ED) among patients with gout have produced inconsistent evidence. Therefore, the aim of this meta-analysis was to investigate the relationship between gout and the risk of ED. The Embase, Medline, Scopus, Web of Science and Cochrane Library databases were searched for all studies assessing the risk of ED in patients with gout. Relative risks (RR) and corresponding 95% confidence intervals (CI) were adopted to estimate the association between gout and the risk of ED. Sensitivity analyses were applied to evaluate the robustness of results. Overall, 355,761 participants were included from 8 studies (3 cross-sectional and 5 cohort studies). Of these, 85,067 were patients with gout. Synthesis results showed patients with gout had a 1.2-fold higher risk of ED than individual without gout (RR 1.20, 95% CI 1.10–1.31, P < 0.001). The results of sensitivity analysis are consistent with the trend of synthesis results. The present meta-analysis revealed that the risk of ED in patients with gout was dramatically increased when compared with the general population, which suggests that clinicians should assess erectile function when treating an individual who suffers from gout.


Gout Erectile dysfunction Meta-analysis 



This work was supported by the grants from Science and Technology Planning Project of Guangdong Province (No. 2017B030314108).

Author contributions

Conception or design of the work: ZGZ and LML. Data collection: QX and YHD. Data analysis and interpretation: SKZ, ZGZ and YZL. Drafting the article: LML. Critical revision of the article: ZGZ, JMW. Final approval of the version to be published: ZGZ and LML. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Supplementary material

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Supplementary Figure 1. Sensitivity analysis after each study was excluded by turns. (TIFF 1938 kb)
296_2019_4365_MOESM2_ESM.doc (53 kb)
Supplementary material 2 (DOC 53 kb)
296_2019_4365_MOESM3_ESM.doc (31 kb)
Supplementary material 3 (DOC 31 kb)
296_2019_4365_MOESM4_ESM.doc (34 kb)
Supplementary material 4 (DOC 34 kb)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Urology and Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of UrologyThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina

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