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Rheumatology International

, Volume 39, Issue 6, pp 1045–1051 | Cite as

Cancer incidence in familial Mediterranean fever patients: a retrospective analysis from central Anatolia

  • Emre Bilgin
  • Ömer Dizdar
  • Deniz Can Güven
  • Serdar Ceylan
  • Özge Aybi
  • Büşra Fırlatan
  • Rıza Can Kardaş
  • Tolga Yıldırım
  • Mutlu Kadir Hayran
  • Umut KalyoncuEmail author
  • Seza Özen
Observational Research

Abstract

Although chronic inflammation has been associated with increased cancer risk in various disease including hepatitis or inflammatory bowel disease, a lower incidence of cancer has been reported recently in familial Mediterranean fever (FMF) which is an auto-inflammatory disease with persistent inflammation. We have assessed cancer incidence among FMF patients with or without amyloidosis to investigate this hypothesis. We performed a retrospective review of FMF patients, diagnosed and treated in Hacettepe University hospitals between 2001 and 2018. We identified patients from the hospital medical records using the ICD-10 code for FMF. We collected data on demographic and clinical features, drug history, the presence of amyloidosis and subsequent diagnosis of cancer. The expected cancer incidence was estimated using age- and gender-specific standardized incidence rates (SIRs) in comparison with the general Turkish population according to Turkish National Cancer Registry data at 2014. Total of 3899 FMF patients (120 patients had also amyloidosis) were included. Median age was 22 and 56% were females. Thirty-eight patients were diagnosed with cancer during 100,283 person-years of follow-up. The most common cancer was breast cancer in females (7/28 patients) and leukemia (2/10 patients) in males. The overall cancer incidence among patients with FMF was significantly lower in both males {SIR 0.42 [95% confidence interval; (CI) 0.21–0.75], p = 0.019} and females [SIR 065 (95% CI 0.44–0.93), p = 0.002]. The overall cancer incidence among patients with FMF and amyloidosis was [SIR 1.21 (95% CI 0.49–2.52), p = 0.73] without gender difference. Cancer incidence was significantly lower in FMF patients compared with the general Turkish population. We found no increased cancer incidence in FMF patients having amyloidosis. Possible underlying mechanisms need to be explained.

Keywords

Familial Mediterranean fever Amyloidosis Cancer Standardized incidence ratio 

Notes

Acknowledgements

Language editing was done by an online and licensed tool.

Author contributions

All authors participated in study design, data collection, analysis, interpretation and writing equally.

Funding

None.

Compliance with ethical standards

Conflict of interest

None of the authors have any potential conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Division of Rheumatology, Department of Internal MedicineHacettepe University Medical SchoolAnkaraTurkey
  2. 2.Department of Preventive OncologyHacettepe University Medical SchoolAnkaraTurkey
  3. 3.Division of Medical Oncology, Department of Internal MedicineHacettepe University Medical SchoolAnkaraTurkey
  4. 4.Department of Internal MedicineHacettepe University Medical SchoolAnkaraTurkey
  5. 5.Division of Nephrology, Department of Internal MedicineHacettepe University Medical SchoolAnkaraTurkey
  6. 6.Division of Pediatric Rheumatology, Department of PediatricsHacettepe University Medical SchoolAnkaraTurkey

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