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Rheumatology International

, Volume 38, Issue 9, pp 1651–1660 | Cite as

Performance of the 2016 ACR-EULAR classification criteria for primary Sjogren’s syndrome in a Korean cohort

  • Jennifer Lee
  • Jung Hee Koh
  • Ji-Won Kim
  • Yoon-Kyoung Sung
  • Shin-Seok Lee
  • Jung Yoon Choe
  • Seung-Cheol Shim
  • Hyun-Sook Kim
  • Hae-Rim Kim
  • Ji-Min Kim
  • Sung Ryul Kwon
  • Hyun-Ok Kim
  • Kichul Shin
  • Chang Hoon Lee
  • So-Hyang Chung
  • Seung-Ki Kwok
  • Ji Hyeon Ju
  • Sung-Hwan ParkEmail author
Classification Criteria
  • 285 Downloads

Abstract

This study compared the performance of the newly proposed 2016 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria to the 2002 American–European Consensus Group (AECG) and 2012 ACR classification criteria for primary Sjogren’s syndrome (pSS) in well-characterized Korean patients. Patients with pSS from 12 university-affiliated hospitals in Korea were enrolled from October 2013 to January 2017. Clinical and laboratory data were reviewed. For the validation set, patients who underwent evaluation tests to rule out pSS at Seoul St. Mary’s hospital from November 2016 to December 2017 were analyzed. Baseline registry data were available in 458 patients, and 328 patients had sufficient data to determine the fulfillment of each criteria set. All three sets of criteria were met by 307 patients (93.6%). The newly proposed 2016 ACR/EULAR criteria were met by 325 patients (99.1%). The 2002 AECG and 2012 ACR criteria were met by 325 (99.1%) and 310 patients (94.5%), respectively. In a validation cohort consisting of 161 patients with pSS-related symptoms/signs, the sensitivity and specificity of the 2016 ACR/EULAR criteria were 100% [95% confidence interval (CI), 96.11–100.00] and 81.8% [95% CI, 76.15–94.26], respectively. Agreement between the 2016 criteria and 2012 or 2002 criteria was high (Cohen’s kappa 0.736 and 0.769, respectively). The newly proposed 2016 ACR/EULAR criteria were met by most patients diagnosed with pSS according to previous criteria and showed higher sensitivity and lower specificity compared with both previous criteria sets.

Keywords

Classification criteria Sjogren’s syndrome 

Notes

Acknowledgements

This study was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (HI13C0016).

Author contributions

JL and SHP contributed to the study design, data collection, data analysis, interpretation of the results, and preparation of the manuscript. JHK, JWK, YKS, SSL, JYC, SCS, HSK, HRK, JMK, SRK, HOK, KS, CHL, SHC, SKK, and JHJ contributed to data collection. All the authors read and approved the final manuscript.

Compliance with ethical standards

Conflict of interest

Jennifer Lee, Jung Hee Koh, Ji-Won Kim, Yoon-Kyoung Sung, Shin-Seok Lee, Jung Yoon Choe, Seung-Cheol Shim, Hyun-Sook Kim, Hae-Rim Kim, Ji-Min Kim, Sung Ryul Kwon, Hyun-Ok Kim, Kichul Shin, Chang Hoon Lee, So-Hyang Chung, Seung-Ki Kwok, Ji Hyeon Ju, and Sung-Hwan Park declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea
  2. 2.Department of RheumatologyHanyang University Hospital for Rheumatic DiseasesSeoulRepublic of Korea
  3. 3.Department of RheumatologyChonnam National University Medical School and HospitalGwangjuRepublic of Korea
  4. 4.Division of RheumatologyDaegu Catholic University Medical CenterDaeguRepublic of Korea
  5. 5.Division of Rheumatology, Department of Internal Medicine, School of Medicine, Chungnam National UniversityChungnam National University HospitalDaejeonRepublic of Korea
  6. 6.Division of Rheumatology, Department of Internal Medicine, Soonchunhyang University Seoul HospitalSoonchunhyang University College of MedicineSeoulRepublic of Korea
  7. 7.Division of Rheumatology, Department of Internal MedicineKonkuk University School of MedicineSeoulRepublic of Korea
  8. 8.Division of Rheumatology, Department of Internal MedicineKeimyung University Dongsan Medical CentreDaeguRepublic of Korea
  9. 9.Division of Rheumatology, Department of Internal MedicineInha University School of MedicineIncheonRepublic of Korea
  10. 10.Division of Rheumatology, Department of Internal MedicineGyeongsang National University Changwon HospitalChangwonRepublic of Korea
  11. 11.Division of Rheumatology, Department of Internal MedicineSNU Boramae Medical CenterSeoulRepublic of Korea
  12. 12.Department of Internal MedicineWonkwang University College of MedicineIksanRepublic of Korea
  13. 13.Department of Ophthalmology and Visual Science, Seoul St Mary’s Hospital, College of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

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