Rheumatology International

, Volume 38, Issue 7, pp 1307–1309 | Cite as

Carpal tunnel syndrome treatment with palmitoylethanolamide: neurophysiology and ultrasound show small changes in the median nerve

  • Daniele CoraciEmail author
  • Claudia Loreti
  • Giuseppe Granata
  • Maria Felice Arezzo
  • Luca Padua

We have read with attention the paper by Güner et al. about the use of lower-power laser and kinesio taping in carpal tunnel syndrome (CTS) [1]. The authors enrolled 37 patients presenting mild or moderate CTS, diagnosed by neurophysiology [1]. The patients were divided into three groups, to compare the effects of low-power laser therapy, kinesio taping associated with the same type of laser and sham laser. This specific treatment was applied for 3 weeks. The authors considered different outcome measures: visual numeric pain scale, hand grip strength, finger pinch strength, Boston Carpal Tunnel Questionnaire. The evaluations were performed before the therapy, after the treatment and three months later. Güner et al. found the patients managed with the two real treatments showed significant improvements in comparison with the sham one [1]. This work sheds light on specific conservative treatments of CTS, not only throughout questionnaires, but also with more objective measurements (like...



The research was partially founded from Epitech Group SpA.

Compliance with ethical standards

Conflict of interest

Daniele Coraci declares that he has no conflict of interest. Claudia Loreti declares that she has no conflict of interest. Giuseppe Granata declares that she has no conflict of interest. Maria Felice Arezzo declares that he has no conflict of interest. Luca Padua declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from the participant included in the study.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.IRCCS Fondazione Don Carlo GnocchiMilanItaly
  2. 2.Department of Geriatrics, Neurosciences, Orthopaedics and Head-NeckUniversità Cattolica del Sacro CuoreRomeItaly
  3. 3.Department of Methods and Models for Economics, Territory and Finance“Sapienza” University of RomeRomeItaly

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