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Monogenic systemic lupus erythematosus: insights in pathophysiology

Rheumatology International volume 38, pages 1763–1775 (2018)Cite this article

Abstract

Systemic lupus erythematosus (SLE) is a complex disease with different genetic, immunologic, and environmental factors contributing to the pathogenesis. Monogenic SLE could help us understand the main phases of immune dysregulation in SLE. The aim of this review is to summarize the current knowledge on monogenic SLE with the implications of the respective genes on disease pathogenesis. A comprehensive literature search on monogenic SLE was conducted utilizing the Cochrane Library and MEDLINE/PubMed databases. The main affected pathways in disease pathogenesis are identified as follows: complement system, apoptosis, nucleic acid degradation, nucleic acid sensing, self-tolerance, and type I interferon production. Further studies on monogenic SLE can make precision medicine possible for SLE by increasing our understanding of disease pathogenesis.

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  1. Department of Pediatrics, Division of Rheumatology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, 06100, Turkey

    Ezgi Deniz Batu

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  1. Ezgi Deniz Batu
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BED designed the structure of the article, drafted and critically revised the text, and approved the final version of the manuscript.

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Batu, E.D. Monogenic systemic lupus erythematosus: insights in pathophysiology. Rheumatol Int 38, 1763–1775 (2018). https://doi.org/10.1007/s00296-018-4048-7

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Keywords

  • Systemic lupus erythematosus
  • Monogenic SLE
  • Complement system
  • Apoptosis
  • Self-tolerance