Skip to main content
SpringerLink
Log in

The TT genotype of the rs6860 polymorphism of the charged multivesicular body protein 1A gene is associated with susceptibility to fibromyalgia in southern Spanish women

  • Correspondence
  • Published:
Rheumatology International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Barbosa FR, Matsuda JB, Mazucato M et al (2012) Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients. Rheumatol Int 32:427–430. https://doi.org/10.1007/s00296-010-1659-z

    Article  CAS  PubMed  Google Scholar 

  2. Salgueiro M, García-Leiva JM, Ballesteros J et al (2013) Validation of a Spanish version of the Revised Fibromyalgia Impact Questionnaire (FIQR). Health Qual Life Outcomes 11:132. https://doi.org/10.1186/1477-7525-11-132

    Article  PubMed  PubMed Central  Google Scholar 

  3. Zhang L, Zhu J, Chen Y, Zhao J (2014) Meta-analysis reveals a lack of association between a common catechol-O-methyltransferase (COMT) polymorphism val158met and fibromyalgia. Int J Clin Exp Pathol 7:8489–8497

    PubMed  PubMed Central  Google Scholar 

  4. Oezel L, Then H, Jung AL et al (2016) Fibromyalgia syndrome: metabolic and autophagic processes in intermittent cold stress mice. Pharmacol Res Perspect 4:e00248. https://doi.org/10.1002/prp2.248

    Article  PubMed  PubMed Central  Google Scholar 

  5. Cordero MD, De Miguel M, Moreno Fernández AM et al (2010) Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. Arthritis Res Ther 12:R17. https://doi.org/10.1186/ar2918

    Article  PubMed  PubMed Central  Google Scholar 

  6. Taylor P, Wang Y, Serricchio M et al (2015) mitophagy Deubiquitinating enzymes regulate PARK2- mediated mitophagy. 37–41. https://doi.org/10.1080/15548627.2015.1034408

  7. Magraoui F, Reidick C, Meyer H, Platta H (2015) Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease. Cells 4:596–621. https://doi.org/10.3390/cells4040596

    Article  PubMed  PubMed Central  Google Scholar 

  8. Kumar V, Westra H-J, Karjalainen J et al (2013) Human disease-associated genetic variation impacts large intergenic non-coding RNA expression. PLoS Genet 9:e1003201. https://doi.org/10.1371/journal.pgen.1003201

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Moszyńska A, Gebert M, Collawn JF, Bartoszewski R (2017) SNPs in microRNA target sites and their potential role in human disease. Open Biol. https://doi.org/10.1098/rsob.170019

    PubMed  PubMed Central  Google Scholar 

  10. Estévez-López F, Segura-Jiménez V, Álvarez-Gallardo IC, Borges-Cosic M, Pulido-Martos M, Carbonell-Baeza A et al (2017) Adaptation profiles comprising objective and subjective measures in fibromyalgia: the al-Ándalus project. Rheumatology 56(11):2015–2024

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

The authors gratefully acknowledge all participants for their collaboration and enthusiasm. We would like to thank the collaborators in the al-Ándalus project and to all the members of the Physical Activity for Health Promotion (PA-HELP; CTS-1018) research group. We would also like to thank Ms. Gema García (Genomic unit, Genyo) for her helpful support in DNA extraction and genotyping of the samples. We are grateful to Ms. Carmen Sainz-Quinn for assistance with the English language. This study is part of a PhD thesis conducted in the Biomedicine Doctoral Studies of the University of Granada, Granada, Spain. This work was supported by the Spanish Ministry of Economy and Competitiveness [I+D+i DEP2010-15639, I+D+i DEP2013-40908-R to M.D.-F.; BES-2014-067612 to F.E.-L.]; the Consejería de Turismo, Comercio y Deporte, Junta de Andalucía [CTCD-201000019242-TRA to M.D.-F.]. The study was partially supported by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES). The funders of the present study did not have any role in the study design, data collection and analyses, decision to publish, or preparation of the manuscript.

Author information

Authors and Affiliations

  1. Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain

    Fernando Estévez-López & Manuel Delgado-Fernández

  2. Department of Psychology, Faculty of Social and Behavioural Sciences, Utrecht University, Utrecht, The Netherlands

    Fernando Estévez-López

  3. Department of Physiology, Faculty of Pharmacy, Faculty of Sport Sciences, and Institute of Nutrition and Food Technology, University of Granada, Granada, Spain

    Virginia A. Aparicio

  4. PROFITH “PROmoting FITness and Health Through Physical Activity” Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain

    Jonatan R. Ruiz

  5. GENYO (Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research), Av. Ilustracion, 114-PTS, 18016, Granada, Spain

    Luis J. Martínez-González & María J. Álvarez-Cubero

  6. Department of Biochemistry & Molecular Biology III, Faculty of Medicine, University of Granada, Granada, Spain

    María J. Álvarez-Cubero

Authors
  1. Fernando Estévez-López
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Virginia A. Aparicio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jonatan R. Ruiz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Luis J. Martínez-González
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Manuel Delgado-Fernández
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. María J. Álvarez-Cubero
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Conception and design of the research: FE-L, VA-A, JR-R, LJM-G, MD-F, and MJA-C; collected the data: FE-L and VA-A; analysed the samples in the laboratory: LJM-G and MJA-C; analysed the data: FE-L, VA-A, and JRR; interpreted the results: FE-L, JRR, LJM-G, MD-F, and MJA-C; drafted the manuscript: FE-L, LJM-G, JRR, and MJA-C; critically revised the manuscript and approved the final version: all the authors.

Corresponding author

Correspondence to Fernando Estévez-López.

Ethics declarations

Conflict of interest

F.E.-L; V.A.A.; J.R.R.; L.J.M.-G.; M.D.-F. and M.J.A.-C. declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Estévez-López, F., Aparicio, V.A., Ruiz, J.R. et al. The TT genotype of the rs6860 polymorphism of the charged multivesicular body protein 1A gene is associated with susceptibility to fibromyalgia in southern Spanish women. Rheumatol Int 38, 531–533 (2018). https://doi.org/10.1007/s00296-017-3896-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-017-3896-x

Search

Navigation