Skip to main content
SpringerLink
Log in

Monocyte chemoattractant protein-1 as a marker of systemic lupus erythematosus: an observational study

  • Biomarkers
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

There is a pivotal need for new markers to be tested in every day clinical practice for systemic lupus erythematosus (SLE) and lupus nephritis (LN). The levels of monocyte chemoattractant protein-1 (MCP-1) in the serum and urine of 72 SLE patients (27 with LN and 45 without LN involvement) and 30 healthy individuals were studied to establish their clinical significance. The SLE Disease Activity Index (SLEDAI) was used to establish the disease activity. Urine and serum MCP-1 was determined using the sandwich enzyme immunosorbent assay. Urinary, but not serum MCP-1, positively correlated with proteinuria (r = 0.839; p < 0.001) and negatively correlated with glomerular filtration, evaluated using the modification of diet in renal disease (MDRD) formula (r = − 0.293; p < 0.05), and with C3 complement component in active LN patients (r = − 0.519, p = 0.019). Both serum and urinary MCP-1 demonstrated a positive correlation with SLEDAI (r = 0.318; p < 0.01 and r = 0.431; p < 0.001). We also demonstrated that the levels of serum and urinary MCP-1 were significantly higher in patients with SLE compared to healthy controls, regardless of the disease activity and renal involvement. We recommend MCP-1 measurement in the routine laboratory follow-up of the SLE patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Qin L, Mohan C (2016) Non-invasive biomarkers for systemic lupus erythematosus: a lookback at 2016. Int J Rheum Dis 19(12):1209–1215

    Article  PubMed  Google Scholar 

  2. Mok CC (2010) Biomarkers for lupus nephritis: a critical appraisal. J Biomed Biotechnol 2010:638413

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  3. Wu Y, Cai B, Zhang J, Shen B, Huang Z, Tan C, Baan CC, Wang L (2017) IL-1β and IL-6 are highly expressed in RF+ IgE+ systemic lupus erythematous subtype. J Immunol Res 2017:5096741. https://doi.org/10.1155/2017/5096741

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  4. Li Y, Tucci M, Narain S et al (2006) Urinary biomarkers in lupus nephritis. Autoimmun Rev 5(6):383–388

    Article  PubMed  CAS  Google Scholar 

  5. Herbst R, Liu Z, Jallal B, Yao Y (2012) Biomarkers for systemic lupus erythematosus. Int J Rheum Dis 15(5):433–44

    Article  PubMed  CAS  Google Scholar 

  6. Ahearn JM, Liu CC, Kao AH, Manzi S (2012) Biomarkers for systemic lupus erythematosus. Transl Res 159(4):326–42

    Article  PubMed  CAS  Google Scholar 

  7. Rovin BH, Zhang X (2009) Biomarkers for lupus nephritis: the quest continues. Clin J Am Soc Nephrol 4(11):1858–1865

    Article  PubMed  CAS  Google Scholar 

  8. Alzawawy A, Zohary M, Ablordiny M, Eldalie M (2009) Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis. Int J Rheum Dis 12(4):311–318

    Article  PubMed  Google Scholar 

  9. Watson L, Midgley A, Pilkington C et al (2012) Urinary monocyte chemoattractant protein 1 and alpha 1 acid glycoprotein as biomarkers of renal disease activity in juvenile-onset systemic lupus erythematosus. Lupus 21(5):496–501

    Article  PubMed  CAS  Google Scholar 

  10. Rahman A (2012) Can measuring urinary biomarkers improve the management of lupus nephritis? Arthritis Res Ther 14(6):127

    Article  PubMed  PubMed Central  Google Scholar 

  11. El-Shehaby A, Darweesh H, El-Khatib M et al (2011) Correlations of urinary biomarkers, TNF-like weak inducer of apoptosis (TWEAK), osteoprotegerin (OPG), monocyte chemoattractant protein-1 (MCP-1), and IL-8 with lupus nephritis. J Clin Immunol 31(5):848–56

    Article  PubMed  CAS  Google Scholar 

  12. Torabinejad S, Mardani R, Habibagahi Z et al (2012) Urinary monocyte chemotactic protein-1 and transforming growth factor-β in systemic lupus erythematosus. Indian J Nephrol 22(1):5–12

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Bauer JW, Petri M, Batliwalla FM et al (2009) Interferon-regulated chemokines as biomarkers of systemic lupus erythematosus disease activity: a validation study. Arthritis Rheum 60(10):3098–107

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  14. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725

    Article  PubMed  CAS  Google Scholar 

  15. Petri M, Hellmann D, Hochberg M (1992) Validity and reliability of lupus activity measures in the routine clinic setting. J Rheumatol 19(1):53–9

    PubMed  CAS  Google Scholar 

  16. Abujam B, Cheekatla S, Aggarwal A (2013) Urinary CXCL-10/IP-10 and MCP-1 as markers to assess activity of lupus nephritis. Lupus 22(6):614–23

    Article  PubMed  CAS  Google Scholar 

  17. Singh RG, Usha, Rathore SS et al (2012) Urinary MCP-1 as diagnostic and prognostic marker in patients with lupus nephritis flare. Lupus 21(11):1214–1218

  18. Vega L, Barbado J, Almansa R et al (2010) Prolonged standard treatment for systemic lupus erythematosus fails to normalize the secretion of innate immunity-related chemokines. Eur Cytokine Netw 21(1):71–6

    PubMed  CAS  Google Scholar 

  19. Barbado J, Martin D, Vega L et al (2012) MCP-1 in urine as biomarker of disease activity in systemic lupus erythematosus. Cytokine 60(2):583–586

    Article  PubMed  CAS  Google Scholar 

  20. Rovin BH, Song H, Birmingham DJ et al (2005) Urine chemokines as biomarkers of human systemic lupus erythematosus activity. J Am Soc Nephrol 16(2):467–73

    Article  PubMed  CAS  Google Scholar 

  21. Tian S, Li J, Wang L et al (2007) Urinary levels of RANTES and M-CSF are predictors of lupus nephritis flare. Inflamm Res 56(7):304–10

    Article  PubMed  CAS  Google Scholar 

  22. Rosa RF, Takei K, Araújo NC et al (2012) Monocyte chemoattractant-1 as a urinary biomarker for the diagnosis of activity of lupus nephritis in Brazilian patients. J Rheumatol 39(10):1948–1954

    Article  PubMed  CAS  Google Scholar 

  23. Alharazy S, Kong NC, Mohd M et al (2015) Urine monocyte chemoattractant protein-1 and lupus nephritis disease activity: preliminary report of a prospective longitudinal study. Autoimmune Dis 2015:962046

    PubMed  PubMed Central  Google Scholar 

  24. Watson L, Tullus K, Pilkington C et al (2014) Urine biomarkers for monitoring juvenile lupus nephritis: a prospective longitudinal study. Pediatr Nephrol 29(3):397–405

    Article  PubMed  Google Scholar 

  25. Bennett M, Brunner HI (2013) Biomarkers and updates on pediatrics lupus nephritis. Rheum Dis Clin North Am 39(4):833–53

    Article  PubMed  PubMed Central  Google Scholar 

  26. Brunner HI, Bennett MR, Mina R et al (2012) Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis. Arthritis Rheum 64(8):2687–2697

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  27. Adhya Z, Borozdenkova S, Karim MY (2011) The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis. Nephrol Dial Transplant 26(10):3273–3280

    Article  PubMed  CAS  Google Scholar 

  28. Liao X, Pirapakaran T, Luo XM (2016) Chemokines and chemokine receptors in the development of lupus nephritis. Mediators Inflamm 2016:6012715

    PubMed  PubMed Central  Google Scholar 

  29. Misra R, Gupta R (2015) Biomarkers in lupus nephritis. Int J Rheum Dis 18(2):219–32

    Article  PubMed  Google Scholar 

  30. Susianti H, Iriane VM, Dharmanata S et al (2015) Analysis of urinary TGF-β1, MCP-1, NGAL, and IL-17 as biomarkers for lupus nephritis. Pathophysiology 22(1):65–71

    Article  PubMed  CAS  Google Scholar 

  31. Gupta R, Yadav A, Aggarwal A (2016) Longitudinal assessment of monocyte chemoattractant protein-1 in lupus nephritis as a biomarker of disease activity. Clin Rheumatol 35(11):2707–2714

    Article  PubMed  Google Scholar 

  32. Umare VD, Pradhan VD, Rajadhyaksha AG, Ghosh K, Nadkarni AH (2017) A functional SNP MCP-1 (-2518A/G) predispose to renal disorder in Indian systemic lupus erythematosus patients. Cytokine 96:189–194

    Article  PubMed  CAS  Google Scholar 

  33. Kiani AN, Johnson K, Chen C et al (2009) Urine osteoprotegerin and monocyte chemoattractant protein-1 in lupus nephritis. J Rheumatol 36(10):2224–2230

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Medicine, University of Niš, Niš, Serbia

    Valentina Živković, Tatjana Cvetković, Branka Mitić, Bojana Stamenković, Sonja Stojanović & Biljana Radovanović-Dinić

  2. Institute for Treatment and Rehabilitation, Niška Banja, Niš, Serbia

    Valentina Živković, Bojana Stamenković & Sonja Stojanović

  3. Clinic of Nephrology Niš, Clinical Centre Niš, Niš, Serbia

    Tatjana Cvetković & Branka Mitić

  4. Clinic of Gastroenterology and Hepatology, Clinical Centre Niš, Niš, Serbia

    Biljana Radovanović-Dinić

  5. Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

    Vladimir Jurišić

Authors
  1. Valentina Živković
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tatjana Cvetković
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Branka Mitić
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Bojana Stamenković
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sonja Stojanović
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Biljana Radovanović-Dinić
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Vladimir Jurišić
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

VŽ wrote the article. VŽ, TC, BM, BJ SS, BR collected patients and diagnosed them. VJ corrected the work, and contributed to the final version of the paper.

Corresponding author

Correspondence to Vladimir Jurišić.

Ethics declarations

Conflict of interest

Authors declare that there are no conflicts of interest.

Informed consent

Before enrollment in the study, all the examinees were informed about the study’s objectives and their informed written consent was obtained. The Ethics Committee of the Faculty of Medicine in Niš (number 01-244-5) and Ethics Committee of the Institute “Niška Banja” (number 03-13661/1) approved of the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Živković, V., Cvetković, T., Mitić, B. et al. Monocyte chemoattractant protein-1 as a marker of systemic lupus erythematosus: an observational study. Rheumatol Int 38, 1003–1008 (2018). https://doi.org/10.1007/s00296-017-3888-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-017-3888-x

Keywords

Search

Navigation