Skip to main content

Advertisement

SpringerLink
Log in

A single recent injury is a potent risk factor for the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative

  • Observational Research
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

We examined the association between previously reported modifiable risk factors for accelerated knee osteoarthritis (AKOA) at the Osteoarthritis Initiative’s (OAI) baseline and 48-month visits among adults who develop AKOA between the 48- and 96-month visits. We conducted a case–control study using data from the OAI baseline to the 96-month visit. Participants had no radiographic knee osteoarthritis (KOA) in the index knee at OAI baseline and 48-month visits [Kellgren–Lawrence (KL) <2]. We classified 2 groups: (1) AKOA: >1 knee developed advance-stage KOA (KL = 3 or 4) between 48- and 96-month visits and (2) No KOA: no KOA and no change in radiographic severity bilaterally over 96 months. We used logistic regression models to evaluate the association between the outcome of AKOA (versus no KOA) and several modifiable risk factors collected at OAI baseline and 48-month visits [body mass index (BMI), systolic blood pressure, comorbidity score, and NSAID use]. We also explored a new injury from baseline to 48 months and from 48- to 96 months. Adults with greater baseline and 48-month BMI were more likely to develop AKOA. Injury was only associated with AKOA onset when it occurred within 4 years of developing AKOA [prior 2 years: odds ratio = 6.21; 95% confidence interval (CI) 3.40, 11.35; 2–4 years prior: odds ratio = 4.42, 95% CI 2.06, 9.50]. BMI may consistently predispose an adult to AKOA, but certain injuries are likely a catalyst for AKOA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Driban JB, Eaton CB, Lo GH, Ward RJ, Lu B, McAlindon TE (2014) Association of knee injuries with accelerated knee osteoarthritis progression: data from the Osteoarthritis Initiative. Arthritis Care Res 66(11):1673–1679. doi:10.1002/acr.22359

    Article  Google Scholar 

  2. Driban JB, Stout AC, Lo GH, Eaton CB, Price LL, Lu B, Barbe MF, McAlindon TE (2016) Best performing definition of accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. Ther Adv Musculoskelet Dis 8(5):165–171. doi:10.1177/1759720X16658032

    Article  PubMed  PubMed Central  Google Scholar 

  3. Driban JB, Eaton CB, Lo GH, Price LL, Lu B, Barbe MF, McAlindon TE (2016) Overweight older adults, particularly after an injury, are at high risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. Clin Rheumatol 35(4):1071–1076. doi:10.1007/s10067-015-3152-2

    Article  PubMed  Google Scholar 

  4. Driban JB, Stout AC, Duryea J, Lo GH, Harvey WF, Price LL, Ward RJ, Eaton CB, Barbe MF, Lu B, McAlindon TE (2016) Coronal tibial slope is associated with accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. BMC Musculoskelet Disord 17:299. doi:10.1186/s12891-016-1158-9

    Article  PubMed  PubMed Central  Google Scholar 

  5. Driban JB, Ward RJ, Eaton CB, Lo GH, Price LL, Lu B, McAlindon TE (2015) Meniscal extrusion or subchondral damage characterize incident accelerated osteoarthritis: data from the Osteoarthritis Initiative. Clin Anat 28(6):792–799. doi:10.1002/ca.22590

    Article  PubMed  PubMed Central  Google Scholar 

  6. Driban JB, Price LL, Eaton CB, Lu B, Lo GH, Lapane KL, McAlindon TE (2015) Individuals with incident accelerated knee osteoarthritis have greater pain than those with common knee osteoarthritis progression: data from the Osteoarthritis Initiative. Clin Rheumatol. doi:10.1007/s10067-015-3128-2

    Google Scholar 

  7. Wallace KD (2016) Older adults with elevated BMI are at greater risk of accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. Wright State University, Dayton

    Google Scholar 

  8. Driban JB, Lo GH, Eaton CB, Price LL, Lu B, McAlindon TE (2015) Knee pain and a prior injury are associated with increased risk of a new knee injury: data from the Osteoarthritis Initiative. J Rheumatol 42(8):1463–1469. doi:10.3899/jrheum.150016

    Article  PubMed  PubMed Central  Google Scholar 

  9. The Osteoarthritis Initiative (2014). http://oai.epi-ucsf.org/. Accessed 20 April 2017

  10. Driban JB, Eaton CB, Amin M, Stout AC, Price LL, Lu B, Lo GH, McAlindon TE, Barbe MF (2017) Glucose homeostasis influences the risk of incident knee osteoarthritis: data from the osteoarthritis initiative. J Orthop Res. doi:10.1002/jor.23531

    Google Scholar 

  11. Riddle DL, Stratford PW, Perera RA (2016) The incident tibiofemoral osteoarthritis with rapid progression phenotype: development and validation of a prognostic prediction rule. Osteoarthr Cartil 24(12):2100–2107. doi:10.1016/j.joca.2016.06.021

    Article  CAS  PubMed  Google Scholar 

  12. Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB (1999) Elevated C-reactive protein levels in overweight and obese adults. JAMA 282(22):2131–2135

    Article  CAS  PubMed  Google Scholar 

  13. Farrokhi S, Voycheck CA, Gustafson JA, Fitzgerald GK, Tashman S (2016) Knee joint contact mechanics during downhill gait and its relationship with varus/valgus motion and muscle strength in patients with knee osteoarthritis. Knee 23(1):49–56

    Article  PubMed  Google Scholar 

  14. Davis J, Eaton CB, Lo GH, Lu B, Price LL, McAlindon TE, Barbe MF, Driban JB (2017) Knee symptoms among adults at risk for accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. Clin Rheumatol. doi:10.1007/s10067-017-3564-2

    Google Scholar 

Download references

Acknowledgements

These analyses were financially supported by a grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award number R01-AR065977. The OAI is a public–private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories; Novartis Pharmaceuticals Corporation, GlaxoSmithKline; and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the National Institutes of Health. This manuscript was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners. This work was also supported in part by the Center for Innovations in Quality, Effectiveness and Safety (#CIN 13-413), Michael E. DeBakey VA Medical Center, Houston, Texas. The views expressed in this article are those of the author(s) and do not necessarily represent the views of the National Institutes of Health or the Department of Veterans Affairs.

Author information

Authors and Affiliations

  1. Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box 406, Boston, MA, 02111, USA

    Julie E. Davis, Timothy E. McAlindon & Jeffrey B. Driban

  2. The Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, USA

    Lori Lyn Price

  3. Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA, USA

    Lori Lyn Price

  4. Medical Care Line and Research Care Line, Houston Health Services Research and Development (HSR&D) Center of Excellence Michael E. DeBakey VAMC, Houston, TX, USA

    Grace H. Lo

  5. Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, TX, USA

    Grace H. Lo

  6. Center for Primary Care and Prevention, Alpert Medical School of Brown University, Pawtucket, RI, USA

    Charles B. Eaton

  7. Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

    Bing Lu

  8. Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, USA

    Mary F. Barbe

Authors
  1. Julie E. Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lori Lyn Price
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Grace H. Lo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Charles B. Eaton
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Timothy E. McAlindon
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Bing Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mary F. Barbe
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jeffrey B. Driban
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jeffrey B. Driban.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Davis, J.E., Price, L.L., Lo, G.H. et al. A single recent injury is a potent risk factor for the development of accelerated knee osteoarthritis: data from the osteoarthritis initiative. Rheumatol Int 37, 1759–1764 (2017). https://doi.org/10.1007/s00296-017-3802-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-017-3802-6

Keywords

Search

Navigation