Rheumatology International

, Volume 37, Issue 12, pp 1949–1956 | Cite as

Urolithiasis as an extraarticular manifestation of ankylosing spondylitis

  • Cengiz KorkmazEmail author
  • Döndü Üsküdar Cansu
  • John A. Sayer
Review on RMDs


Ankylosing spondylitis (AS) affects sacroiliac and axial joints as well as extraarticular organs, such as the eye, lung, bowel, and heart. Although examples of renal involvement in AS, such as IgA nephropathy, amyloidosis, and glomerulonephritis, have been reported, it has not been emphasized that urolithiasis is frequently formed in the clinical course of AS. Growing evidence indicates that urolithiasis may be observed in AS patients and is more frequent than other extraarticular features. In this review, we will discuss frequency and predictors of AS-related urolithiasis and summarize the possible underlying genetic and biochemical mechanisms. We believe an increased awareness of urolithiasis as a complication of AS will encourage future studies that will shed light on disease mechanisms and preventative therapies.


Ankylosing spondylitis Urolithiasis Nephrolithiasis Renal stone Bone Intestinal inflammation 



This study was not funded by any company or other society.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participant performed by any of the authors.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Cengiz Korkmaz
    • 1
    Email author
  • Döndü Üsküdar Cansu
    • 1
  • John A. Sayer
    • 2
  1. 1.Division of Rheumatology, Department of Internal MedicineEskişehir Osmangazi UniversityEskişehirTurkey
  2. 2.Institute of Genetic Medicine, Newcastle UniversityNewcastle upon TyneUK

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