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Analgesic use in patients with knee and/or hip osteoarthritis referred to an outpatient center: a cross-sectional study within the Amsterdam Osteoarthritis Cohort

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Abstract

Although analgesics are widely recommended in current guidelines, underuse and inadequate prescription of analgesics seem to result in suboptimal treatment effects in patients with knee and/or hip osteoarthritis (OA). This study aimed (i) to describe the use of analgesics; and (ii) to determine factors that are related to analgesic use in patients with knee and/or hip OA referred to an outpatient center. A cross-sectional study with data from 656 patients with knee and/or hip OA referred to an outpatient center (Amsterdam Osteoarthritis (AMS-OA) cohort) was conducted. Self-reported use of analgesic (yes/no) was administered and subdivided into acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs, including coxibs) and opioids. Logistic regression analyses were performed to analyze the association between analgesic use and disease-related, predisposing and enabling factors. Analgesic use was reported by 63% of the patients, with acetaminophen, NSAIDs and opioid use reported by 50, 30 and 12%, respectively. Factors related to analgesic use were higher pain severity, longer duration of symptoms, higher radiographic hip OA severity, overweight/obesity and psychological distress. These factors explained 21% of the variance of analgesic use. More than one-third of patients with established knee and/or hip OA referred to an outpatient center did not use any analgesics. Although multiple, mostly disease-related associated factors were found, analgesic use remained predominantly unexplained. Our study seems to indicate that prescription of analgesics should be guided more dominantly by clinical symptoms and needs, and preceded by a thorough shared decision-making process between patient and physician.

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Acknowledgement

We acknowledge M. Steenbergen for preparing data analysis.

Author information

Authors and Affiliations

  1. Amsterdam Rehabilitation Research Center/Reade, Amsterdam, The Netherlands

    Jesper Knoop, Martin van der Esch, Leo D. Roorda & Marike van der Leeden

  2. Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark

    Joyce van Tunen

  3. Department of Rehabilitation Medicine/EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands

    Joost Dekker & Marike van der Leeden

  4. Department of Rheumatology, VU University Medical Center, Amsterdam, The Netherlands

    Willem F. Lems

  5. Jan van Breemen Research Institute/Reade, Amsterdam, The Netherlands

    Willem F. Lems

Authors
  1. Jesper Knoop
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  2. Joyce van Tunen
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  4. Leo D. Roorda
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Correspondence to Jesper Knoop.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Knoop, J., van Tunen, J., van der Esch, M. et al. Analgesic use in patients with knee and/or hip osteoarthritis referred to an outpatient center: a cross-sectional study within the Amsterdam Osteoarthritis Cohort. Rheumatol Int 37, 1747–1755 (2017). https://doi.org/10.1007/s00296-017-3785-3

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  • DOI: https://doi.org/10.1007/s00296-017-3785-3

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