Abstract
The objective of the study was to investigate the frequency of traditional risk factors for the cardiovascular (CV) disease, to calculate the Systematic COronary Risk Evaluation (SCORE) for CV-related mortality in Danish patients with psoriatic arthritis (PsA) and ankylosing spondylitis (AS), and to compare with results from patients with rheumatoid arthritis (RA) from the same settlement. All PsA and AS patients aged 18–85 years from one outpatient clinic were invited. A rheumatology nurse conducted 30-min screening consultation, preceded by a lipid and glucose profile. High SCORE risk led to recommendation of follow-up by general practitioners. Multiple and logistic regression analyses, adjusted for age and gender, were performed, to compare risk factors and risk SCOREs. Participants were 116 AS (29.3% female) and 170 PsA (54.7% female). AS had opposed PsA patients’ lower 10-year risk SCOREs of CV mortality than RA patients: AS versus RA coefficient −0.47 (confidence interval (CI) 95%: −0.84 to −0.) and PsA versus RA −0.14, (−0.43–0.16). Women with PsA and AS had increased waistline compared to women with RA [PsA vs. RA 7.94 (4.51–11.38); AS versus RA 6.67 (1.17–12.17)], and an increased prevalence of hypertension was seen in AS versus RA patients [1.87 (1.15–3.05)]. Traditional, modifiable CV risk factors were present in PsA and AS patients. AS but not PsA patients had an estimated lower 10-year risk of CV mortality than RA patients, according to the SCORE model adjusted for age and gender.
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Acknowledgements
The authors would like to acknowledge the multidisciplinary steering group for the systematic screening (senior consultants Vibeke Ringsdal, head of the secretariat Anette Christensen, head of the department of clinical chemistry Charlotte Drachmann and the outpatient nurses Pia Rhode Rasmussen, Joan Clausen and Kirsten Nørret Hansen). Thank you to Niels Steen Krogh from Zitelab and the DANBIO registry for cooperation in development of the CVR theme as part of a yearly visit. Thank you to Lorna Campbell for assistance in language editing. Funding was provided by Gigtforeningen (DK) (Grant No. R116-A2801).
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This study was funded by a research grant from the Association against Rheumatism (Gigtforeningen; patient organization), Denmark. Author 1 has received financial support from Bristol-Myers Squibb to attend a conference. Authors 2 and 3 have received speaker fees from multiple pharmacological companies, and author 2 has received financial support from multiple different pharmacological companies to attend conferences during the past 10 years.
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The study has been performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and later amendments. The data used in this study were obtained and entered into a national quality database (DANBIO) as part of daily clinical practice. Thus, permission from a research ethics committee was not required and formal informed consent was not obtained.
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Nissen, C.B., Hørslev-Petersen, K. & Primdahl, J. Cardiovascular risk profiles in a hospital-based population of patients with psoriatic arthritis and ankylosing spondylitis: a cross-sectional study. Rheumatol Int 37, 113–120 (2017). https://doi.org/10.1007/s00296-016-3614-0
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DOI: https://doi.org/10.1007/s00296-016-3614-0