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Prevalence, severity, and clinical features of acute and chronic pancreatitis in patients with systemic lupus erythematosus

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Abstract

Pancreatitis is a rare, life-threatening complication of systemic lupus erythematosus (SLE). This study aimed to describe the clinical features of acute pancreatitis (AP) and chronic pancreatitis (CP) in patients with SLE. Data of patients who fulfilled the revised criteria of the American Rheumatism Association for diagnosis of SLE were retrospectively analyzed. SLE activity was graded according to the SLE Disease Activity Index. Logistic regression analysis was conducted to find out independent associations. Survival rates were estimated by using Kaplan–Meier plots. This study included 5665 SLE patients admitted between January 1983 and January 2014, of whom 52 patients were diagnosed with pancreatitis. Pancreatitis prevalence in SLE patients was 0.92 % (52/5665). AP (0.8 %, 46/5665) was more prevalent than CP (0.1 %, 6/5665), presented mostly during active SLE, and affected more organs. Hypertriglyceridemia occurred in 76.9 % of AP patients and in none of the CP patients. AP patients were divided into severe (n = 10) or mild (n = 20) cases. The average triglyceride level in severe AP cases was higher than that in mild AP cases (P = 0.006), and the mortality rate of lupus-associated AP was 32.6 % (15/46). Concomitant infections and thrombocytopenia were independently associated with poor prognosis (P < 0.001, P = 0.028, respectively). There were significant differences in the clinical manifestations of AP and CP. Patients with severe AP were found to have a higher incidence of concomitant infection and serum triglyceride levels. Concomitant infections and thrombocytopenia were independent risk factors for poor prognosis.

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Acknowledgments

This work was supported by the National High Technology Research and Development Program of China (2012AA02A513), the National Nature Science Foundation (81501405) and the Peking Union Medical College Youth Fund 2015 (3332015092).

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Authors and Affiliations

  1. Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

    Qiang Wang & Jiaming Qian

  2. Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, 100730, China

    Min Shen, Xiaomei Leng, Xiaofeng Zeng & Fengchun Zhang

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  1. Qiang Wang
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  2. Min Shen
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  3. Xiaomei Leng
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  4. Xiaofeng Zeng
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  5. Fengchun Zhang
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  6. Jiaming Qian
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Correspondence to Min Shen.

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The authors declare that they have no conflict of interest.

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All procedures performed in the present study were in accordance with the ethical standards of our institutional research committee and with the 1964 Helsinki declaration and its later amendments.

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Informed consent was obtained from all individual participants included in the study.

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Wang, Q., Shen, M., Leng, X. et al. Prevalence, severity, and clinical features of acute and chronic pancreatitis in patients with systemic lupus erythematosus. Rheumatol Int 36, 1413–1419 (2016). https://doi.org/10.1007/s00296-016-3526-z

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  • DOI: https://doi.org/10.1007/s00296-016-3526-z

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