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Table 1 Baseline characteristics, questionnaire results, thermographic assessment and nailfold capillaroscopy in primary RP and FMS

From: Symptoms of Raynaud’s phenomenon (RP) in fibromyalgia syndrome are similar to those reported in primary RP despite differences in objective assessment of digital microvascular function and morphology

  Primary RP (n = 85) FMS (n = 43) p value
Age, mean (SD) 47.8 (14.7) 43.8 (10.8) 0.12
Female, n (%) 66 (77.6) 39 (90.7) 0.07
Smoking history, n (%)
 Never 40 (47) 19 (44.2) 0.76
 Ex 31 (36.5) 8 (18.6) 0.04
 Current 14 (16.5) 16 (37.2) 0.009
Diabetes mellitus, n (%) 2 (2.4) 2 (4.7) 0.48
Hypertension, n (%) 16 (18.8) 3 (7.0) 0.08
Hyperlipidaemia, n (%) 11 (12.9) 1 (2.3) 0.05
Vasodilator use, n (%) 21 (24.7) 14 (32.6) 0.35
Questionnaire results
Cold intolerance, n (%) 80 (94.1) 42 (97.7) 0.37
White, n (%) 60 (69.9) 29 (67.4) 0.71
Blue, n (%) 38 (44.7) 14 (32.6) 0.19
Red, n (%) 37 (43.5) 21 (48.8) 0.57
Purple, n (%) 41 (48.2) 16 (37.2) 0.24
Mono-phasic, n (%) 23 (27.1) 14 (32.6) 0.52
Bi-phasic, n (%) 21 (24.7) 11 (25.6) 0.91
Tri-phasic, n (%) 32 (37.6) 13 (30.2) 0.41
Quadriphasic, n (%) 9 (10.6) 5 (11.6) 0.86
Numbness, n (%) 73 (85.9) 41 (95.3) 0.11
Symptoms in absence of cold, n (%) 47 (55.3) 25 (58.1) 0.76
Thumbs involvement, n (%) 31 (36.5) 17 (39.5) 0.74
Toes involvement, n (%) 66 (77.6) 35 (81.4) 0.62
Thermal imaging
Baseline temperature digits, °C (IQR) 29.0 (7.3) 32.1 (7.3) 0.004
Baseline temperature dorsum, °C (IQR) 30.2 (4.4) 31.9 (4.3) 0.005
Baseline thermal gradient, °C (IQR) −0.9 (3.1) 0.0 (3.0) 0.033
Post-CST temperature digits, °C (IQR) 26.5 (7.4) 30.8 (8.6) 0.003
Post-CST temperature dorsum, °C (IQR) 28.8 (4.1) 30.7 (4.6) 0.003
Post-CST thermal gradient, °C (IQR) −2.6 (4.1) −0.2 (3.6) 0.066
  Primary RP (n = 48) FMS (n = 18) p value
Nailfold capillaroscopy
Normal nailfold capillaroscopy, n (%) 31 (64.6) 15 (83.3) 0.14
Subtle non-specific NC changes, n (%) 15 (31.3) 3 (16.7) 0.24
Scleroderma-like NC changes, n (%) 2 (4.1) 0 (0) 0.38
  1. Analyses of categorical data used Chi-square test. Analysis of continuous data used Mann–Whitney U test
  2. RP Raynaud’s phenomenon, FMS fibromyalgia syndrome, IQR interquartile range, CST cold stress test, NC nailfold capillaroscopy