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Bone and bone marrow involvement in sarcoidosis

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Abstract

Bone and bone marrow involvement in sarcoidosis have been infrequently reported. We aimed to describe the clinical features, radiological descriptions, pathological examinations, and outcomes of three patients with osseous sarcoidosis and one patient with bone marrow sarcoidosis seen at our institution. Our case series included fluorodeoxyglucose positron emission tomography descriptions in assessing the whole-body extent of sarcoidosis. In the era of advanced imaging, large bone and axial skeleton sarcoidosis lesions are more common than previously reported.

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References

  1. Mayock RL, Bertrand P, Morrison CE et al (1963) Manifestations of sarcoidosis. analysis of 145 patients, with a review of nine series selected from the literature. Am J Med 35:67–89

    Article  CAS  PubMed  Google Scholar 

  2. Iannuzzi MC, Rybicki BA, Teirstein AS (2007) Sarcoidosis. N Engl J Med 357:2153–2165

    Article  CAS  PubMed  Google Scholar 

  3. Thelier N, Assous N, Job-Deslandre C, Meyer O, Bardin T, Orcel P, Lioté F, Dougados M, Kahan A, Allanore Y (2008) Osteoarticular involvement in a series of 100 patients with sarcoidosis referred to rheumatology departments. J Rheumatol 35:1622–1628

    PubMed  Google Scholar 

  4. James DG, Neville E, Siltzbach LE (1976) A worldwide review of sarcoidosis. Ann N Y Acad Sci 278:321–334

    Article  CAS  PubMed  Google Scholar 

  5. Brackers de Hugo L, Ffrench M, Broussolle C, Seve P (2013) Granulomatous lesions in bone marrow: clinicopathologic findings and significance in a study of 48 cases. Eur J Intern Med 24:468–473

    Article  PubMed  Google Scholar 

  6. Yaghmai I (1983) Radiographic, angiographic and radionuclide manifestations of osseous sarcoidosis. RadioGraphics 3:375–396

    Article  Google Scholar 

  7. Sparks JA, McSparron JI, Shah N, Aliabadi P, Paulson V, Fanta CH, Coblyn JS (2014) Osseous sarcoidosis: clinical characteristics, treatment, and outcomes–experience from a large, academic hospital. Semin Arthritis Rheum 44:371–379

    Article  PubMed  Google Scholar 

  8. Wilcox A, Bharadwaj P, Sharma OP (2000) Bone sarcoidosis. Curr Opin Rheumato. 12:321–330

    Article  CAS  Google Scholar 

  9. Moore SL, Kransdorf MJ, Schweitzer ME, Murphey MD, Babb JS (2012) Can sarcoidosis and metastatic bone lesions be reliably differentiated on routine MRI? AJR Am J Roentgenol 198:1387–1393

    Article  PubMed  Google Scholar 

  10. Mostard RL, Prompers L, Weijers RE, van Kroonenburgh MJ, Wijnen PA, Geusens PP, Drent M (2012) F-18 FDG PET/CT for detecting bone and bone marrow involvement in sarcoidosis patients. Clin Nucl Med 37:21–25

    Article  PubMed  Google Scholar 

  11. Milman N, Lund JO, Graudal N, Enevoldsen H, Evald T, Nørgård P (2000) Diagnostic value of routine radioisotope bone scanning in a series of 63 patients with pulmonary sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 17:67–70

    CAS  PubMed  Google Scholar 

  12. Browne PM, Sharma OP, Salkin D (1978) Bone marrow sarcoidosis. JAMA 240:2654–2655

    Article  CAS  PubMed  Google Scholar 

  13. Yanardag H, Pamuk GE, Karayel T, Demirci S (2002) Bone marrow involvement in sarcoidosis: an analysis of 50 bone marrow samples. Haematologia (Budap) 32:419–425

    Google Scholar 

  14. Ponce C, Gujral JS (2004) Renal failure and hypercalcemia as initial manifestations of extrapulmonary sarcoidosis. South Med J 97:590–592

    Article  PubMed  Google Scholar 

  15. Saliba WR, Elias MS (2005) Recurrent severe hypercalcemia caused by bone marrow sarcoidosis. Am J Med Sci 330:147–149

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors thank the Marshfield Clinic Research Foundation’s Office of Scientific Writing and Publication for assistance in preparing this manuscript.

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Authors and Affiliations

  1. Department of Rheumatology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, WI, 54449, USA

    Ralph Yachoui

  2. Department of Radiology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, WI, 54449, USA

    Brian J. Parker

  3. Department of Lab-Pathology, Marshfield Clinic, 1000 N. Oak Avenue, Marshfield, WI, 54449, USA

    Thanhcuong T. Nguyen

Authors
  1. Ralph Yachoui
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  2. Brian J. Parker
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  3. Thanhcuong T. Nguyen
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Correspondence to Ralph Yachoui.

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Yachoui, R., Parker, B.J. & Nguyen, T.T. Bone and bone marrow involvement in sarcoidosis. Rheumatol Int 35, 1917–1924 (2015). https://doi.org/10.1007/s00296-015-3341-y

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  • DOI: https://doi.org/10.1007/s00296-015-3341-y

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