Rheumatology International

, Volume 35, Issue 8, pp 1409–1414 | Cite as

The effect of Ramadan fasting on quiescent systemic lupus erythematosus (SLE) patients’ disease activity, health quality of life and lipid profile: a pilot study

  • Hamid Goharifar
  • Seyedeh Tahereh Faezi
  • Pedram Paragomi
  • Ali Montazeri
  • Arash Tehrani Banihashemi
  • Maryam Akhlaghkhah
  • Bahar Sadeghi Abdollahi
  • Zahra Kamazani
  • Mahmood Akbarian
Original Article - Food for Thought

Abstract

SLE is a common autoimmune disease with considerable morbidity. Ramadan fasting is a religious custom Muslims regularly practice. We aimed to evaluate the effect of Ramadan fasting on SLE patients’ disease activity, health quality of life and lipid profile. We conducted this case control study as a pilot study in 40 quiescent SLE patients, 21 cases who decided to fast and 19 controls who decided not to have Ramadan fasting between August and November 2009 in lupus unit of Rheumatology Research Center in Tehran University of Medical Sciences, Iran. They were assessed for SLE Disease Activity Index, lipid profile and quality of life with Short-Form 36 (SF-36) Health Survey, 1 day before Ramadan, the day after and 3 months after Ramadan fasting. After 24.1 ± 5.4 (mean ± SD) days of fasting, anti-ds DNA increased for 0.34 ± 0.41 mmol/dL in cases versus 0.07 ± 0.31 in controls (P = 0.026). Likewise C3 increased more dramatically in cases (16.8 ± 17.5 vs. 2.3 ± 13.2 mg/dL, P = 0.006). Three months after fasting, anti-ds DNA was still increased 0.28 ± 0.46 mmol/dL in cases while a 0.02 ± 0.43 mmol/dL drop in controls was detected (P = 0.04). On the contrary, C3 returned to baseline. These changes were not accompanied with significant changes in disease activity and health quality of life. Ramadan fasting had no effect on lipid profile except for delayed total cholesterol decrease in cases in comparison with controls (16.4 ± 29.4 decrease vs. 4.6 ± 23.9 mg/dL decrease, P = 0.018). Ramadan fasting probably has no detrimental effect on SLE patients’ disease activity and their quality of life in the quiescent phase of disease.

Keywords

Systemic lupus erythematosus Disease activity Lipid profile SF-36 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Hamid Goharifar
    • 1
    • 2
  • Seyedeh Tahereh Faezi
    • 1
  • Pedram Paragomi
    • 1
  • Ali Montazeri
    • 3
  • Arash Tehrani Banihashemi
    • 1
  • Maryam Akhlaghkhah
    • 1
  • Bahar Sadeghi Abdollahi
    • 1
  • Zahra Kamazani
    • 1
  • Mahmood Akbarian
    • 1
  1. 1.Rheumatology Research CenterTehran University of Medical SciencesTehranIran
  2. 2.Department of Internal MedicineHamedan University of Medical ScienceHamedanIran
  3. 3.Iranian Institute for Health Sciences ResearchTehranIran

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