Abstract
The objective of this study was to evaluate the influence of morning stiffness on productivity at work and to estimate the work-related economic consequences of morning stiffness among patients with RA-related morning stiffness in 11 European countries. The original sample comprised 1061 RA patients from 11 European countries (Belgium, Denmark, Finland, France, Germany, Italy, Norway, Poland, Spain, Sweden and UK). They had been diagnosed with RA and experience morning stiffness three or more times per week. Data were collected by interviews. Women comprised 77.9 % of the sample, the average age was 50.4 years, and 84.3 % had RA diagnosed for more than 2 years. Overall costs of RA-related morning stiffness was calculated to be 27,712€ per patient per year, varying from 4965€ in Spain to 66,706€ in Norway. On average, 96 % of the overall production losses were attributed to early retirement, with a markedly lower level (77 %) in Italy than in other countries (p < 0.0001). The proportion of patients who reported retirement due to morning stiffness and productivity losses due to late work arrivals and working while sick showed considerable variation across the countries represented in the study. Overall, the average annual cost of late arrivals (0.8 % of the total costs) was approximately half of the costs attributed to sick leave (1.7 %) and working while sick (1.5 %). Morning stiffness due to RA causes significant production losses and is a significant cost burden throughout Europe. There seem to be notable differences in the impact of morning stiffness on productivity between European countries.
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de Croon EM, Sluiter JK, Nijssen TF, Dijkmans BA, Lankhorst GJ, Frings-Dresen MH (2004) Predictive factors of work disability in rheumatoid arthritis: a systemic literature review. Ann Rheum Dis 63:1362–1367
Walker N, Michaud K, Wolfe F (2005) Work limitations among working persons with rheumatoid arthritis: results, reliability, and validity of the work limitations questionnaire in 836 patients. J Rheumatol 32(6):1006–1012
Puolakka K, Kautiainen H, Möttönen T, Hannonen P, Korpela M, Hakala M et al (2009) A mismatch between self-reported physical work load and the HAQ: early identification of rheumatoid arthritis patients at risk for loss of work productivity. Clin Exp Rheumatol 27:422–429
Puolakka K, Kautiainen H, Möttönen T, Hannonen P, Korpela M, Hakala M et al (2009) Use of Stanford Health Assessment Questionnaire in estimation of long-term productivity costs in patients with recent onset rheumatoid arthritis. Scand J Rheumatol 38:96–103
Ruof J, Hulsemann JL, Mittendorf T, Handelmann S, von der Schulenburg JM, Zeidler H et al (2003) Costs of rheumatoid arthritis in Germany: a micro-costing approach based on healthcare payer’s data source. Ann Rheum Dis 62:544–550
Kobelt G, Jönsson B (2008) The burden of rheumatoid arthritis and access to treatment: outcome and cost-utility of treatments. Eur J Health Econ 8(Suppl 2):S95–S106
Merkersdal S, Ruof J, Huelsemann J, Schoeffski O, Maetzel A, Mau W et al (2001) Development of a matrix of cost domains in economic evaluation of rheumatoid arthritis. J Rheumatol 28:657–661
Hallert E, Husberg M, Skogh T (2006) Costs and course of disease and function in early rheumatoid arthritis: a 3-year follow-up (the Swedish TIRA project). Rheumatology 45:325–331
Huscher D, Merkesdal S, Thiele K, Zeidler H, Scheiner M, Zink A et al (2006) Cost of illness in rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and systemic lupus erythematosus in Germany. Ann Rheum Dis 65:1175–1183
Lundqkvist J, Kastäng F, Kobelt G (2008) The burden of rheumatoid arthritis and access to treatment: health burden and costs. Eur J Health Econ 8(Suppl2):S49–S60
Kobelt G, Lindgren P, Geborek P (2009) Costs and outcomes for patients with rheumatoid arthritis treated with biological drugs in Sweden: a model based on registry data. Scand J Rheumatol 38:409–418
Rat A-C, Boissier M-C (2004) Rheumatoid arthritis: direct and indirect costs. Joint Bone Spine 71:518–524
Kobelt G, Woronoff A-S, Richard B, Peeters P, Sany J (2008) Disease status, costs and quality of life of patients with rheumatoid arthritis in France: the ECO-PR Study. Joint Bone Spine 75:408–415
Doeglas D, Suurmeijer T, Krol B, Sanderman R, van Leeuwen M, van Rijswijk M et al (1995) Work disability in early rheumatoid arthritis. Ann Rheum Dis 54:455–460
Barrett EM, Scott DG, Wiles NJ, Symmons DP (2000) The impact of rheumatoid arthritis on employment status in the early years of disease: a UK community-based study. Rheumatology 39:1403–1409
Sokka T (2003) Work disability in early rheumatoid arthritis. Clin Exp Rheumatol 21:S71–S74
Reisine S, McQuillan J, Fifield J (1995) Predictors of work disability in rheumatoid arthritis patients. A five-year follow up. Arthritis Rheum 38:1630–1637
van Jaarsveld CH, Jacobs JW, Schrijvers AJ, van Albada-Kuipers GA, Hofman DM, Bijlsma JW (1998) Effects of rheumatoid arthritis on employment and social participation during the first years of disease in The Netherlands. Br J Rheumatol 37:848–853
Young A, Dixey J, Kulinskaya E, Cox N, Davies P, Devlin J et al (2002) Which patients stop working because of rheumatoid arthritis? Results of five years’ follow up in 732 patients from the Early RA study (ERAS). Ann Rheum Dis 61:335–340
Hallert E, Husberg M, Bernfort L (2012) The incidence of permanent work disability in patients with rheumatoid arthritis in Sweden 1990–2010: before and after introduction of biologic agents. Rheumatology 51:338–346
Burton W, Morrison A, Maclean R, Ruderman E (2006) Systematic review of studies of productivity loss due to rheumatoid arthritis. Occup Med 56:18–27
Westhoff G, Buttgereit F, Grohmnica-Ihle E, Zink A (2008) Morning stiffness and its influence on early retirement in patients with recent onset rheumatoid arthritis. Rheumatology 47:980–984
Mattila K, Buttgereit F, Tuominen R (2014) Impact of morning stiffness on working behaviour and performance in people with rheumatoid arthritis. Rheumatol Int 34(12):1751–1758
Eberhardt K, Larsson BM, Nived K, Lindqvist E (2007) Work disability in rheumatoid arthritis: development over 15 years and evaluation of predictive factors over time. J Rheumatol 34(3):481–487
Phillips S, Dow L (2012) Impact of impaired morning function on quality of life in rheumatoid arthritis: results of an exploratory patient survey. Int J Clin Rheumatol 7:597–606
Braakman-Jansen L, Taal E, Kuper I, van de Laar M (2012) Productivity loss due to absenteeism and presenteeism by different instruments in patients with RA and Patients without RA. Rheumatology 51:354–361
Bansback N, Zhang W, Walsh D, Kiely P, Williams R, Guh D et al (2012) Factors associated with absenteeism, presenteeism and activity impairment in patients in the first year of RA. Rheumatology 51:375–384
Sogaard R, Sorensen J, Linde L, Hetland ML (2010) The significance of presenteeism for the value of lost production: the case of rheumatoid arthritis. ClinicoEcon Outcomes Res 2:105–112
Neovius M, Simard JF, Askling J (2011) How large are the productivity losses in contemporary patients with RA, and how soon in relation to diagnosis do they develop? Ann Rheum Dis 70:1010–1015
Zhao FL, Xie F, Hu H, Li SC (2013) Transferability of indirect cost of chronic disease: a systematic review and meta-analysis. Pharmacoeconomics 31:501–508
Rosery H, Bergemann R, Maxion-Bergemann S (2005) International variation in resource utilisation and treatment costs for rheumatoid arthritis: a systematic literature review. Pharmacoeconomics 23(3):243–257
Yelin E (1996) The costs of rheumatoid arthritis: absolute, incremental, and marginal estimates. J Rheumatol 23(Suppl44):47–51
Cabrita J, Ortigao M (2012) Working time development—2010. Eurofound. http://www.eurofound.europa.eu/eiro/studies/tn1106010s/tn1106010s.htm/. Accessed 25 Oct 2012
Lee DM, Weinblatt ME (2001) Rheumatoid arthritis. Lancet 358:903–911
Khan N, Yazici Y, Calvo-Alen J et al (2009) Reevaluation of the role of duration of morning stiffness in the assessment of rheumatoid arthritis activity. J Rheumatol 36(11):2435–2442
Eurostat Yearbook (2011) http://epp.eurostat.ec.europa.eu/portal/page/portal/product_details/publication?p_product_code=CH_06_2011/. Accessed 25 Oct 2012
Kobelt G (2007) Thoughts on health economics in rheumatoid arthritis. Ann Rheum Dis 66:iii35–iii39
Yazici Y, Erkan D, Peterson MG, Kagen LJ (2001) Morning stiffness: how common is it and does it correlate with physician and patient global assessment of disease activity? J Rheumatol 28(6):1468–1469
Alavinia SM, Burdorf A (2008) Unemployment and retirement and ill-health: a cross-sectional analysis across European countries. Int Arch Occup Environ Health 82(1):39–45
Acknowledgments
The pan-European survey on which the reported productivity analyses are based was conducted by Ipsos MORI and funded by Mundipharma International Limited. Diane Storey of DPS Limited provided editorial support, with funding provided by Mundipharma International Limited. This survey on which the reported productivity analyses are based was funded by Mundipharma International Limited.
Conflict of interest
Dr. Mattila has no conflict of interest. Dr. Buttgereit reported receiving consultancy fees, honoraria and travel expenses from Merck Serono, Horizon Pharma (formerly Nitec Pharma) Mundipharma Int Ltd and grant support from Merck Serono and Horizon Pharma. Dr. Tuominen reported receiving consultancy fees, honoraria or travel expenses from Wyeth/Pfizer, Mundipharma Int Ltd, Mundipharma Finland Ltd, Orion Pharmacy, MSD, MODZ and GSK.
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Technical note A quota sample of adults of working age (aged 18 years to the official retirement age in each country) who have suffered from rheumatoid arthritis for 6 months and who suffer from morning stiffness as a result of their rheumatoid arthritis for three mornings a week was interviewed. Countries in which the survey was carried out are Belgium, Denmark, Finland, France, Germany, Italy, Norway, Poland, Spain, Sweden and the UK. Quota controls were set on gender (70 % female, 30 % male) to reflect the profile of this audience. Soft quotas were set on age (at least 25 % of sample 18–45 years old, at least 25 % 46–55 years old, at least 25 % 56—national retirement age) to ensure robust analysis could be conducted based on age. All interviews were carried out over the telephone between April 2011 and July 2011 by Ipsos MORI. Detailed analysis of the data was carried out at the University of Turku, Finland. If further technical details are required, please contact kamatt@utu.fi. For a copy of the exact question wording or more technical sampling details, please contact kamatt@utu.fi.
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Mattila, K., Buttgereit, F. & Tuominen, R. Influence of rheumatoid arthritis-related morning stiffness on productivity at work: results from a survey in 11 European countries. Rheumatol Int 35, 1791–1797 (2015). https://doi.org/10.1007/s00296-015-3275-4
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DOI: https://doi.org/10.1007/s00296-015-3275-4