Rheumatology International

, Volume 35, Issue 2, pp 315–322 | Cite as

Hypovitaminosis D in widespread pain: its effect on pain perception, quality of life and nerve conduction studies

  • Pinar Kuru
  • Gulseren AkyuzEmail author
  • Ilker Yagci
  • Esra Giray
Original Article


The aim of the study was to investigate the effects of hypovitaminosis D on pain, quality of life (QoL) and nerve conduction studies (NCSs) in patients with chronic widespread pain (CWP). We randomly selected 83 female patients with CWP according to their vitamin D levels in this cross-sectional study. Patients were divided into two groups as sufficient vitamin D level (above 20 ng/ml) and deficient vitamin D level (below 20 ng/ml, hypovitaminosis D). Various pain scales and Nottingham Health Profile (NHP) were used. NCSs were also done. In patients with hypovitaminosis D, there were significantly higher pain scores for all scales (p value range 0.002–0.027). The subscale and total NHP scores were significantly higher in hypovitaminosis D group (p = 0.048–0.001) except social isolation subscale (p = 0.553). Vitamin D levels were in negative correlation with right and left median and/or ulnar motor nerve amplitudes, left tibial motor amplitude. This study confirm that hypovitaminosis D is related with higher pain intensity and lower QoL scores in patients with CWP when compared with control group. Additionally, we identified for the first time that there were negative correlations between vitamin D levels and some findings of NCSs.


Vitamin D deficiency Chronic pain Female Nothingham Health Profile 


Conflict of interest

We certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Pinar Kuru
    • 1
  • Gulseren Akyuz
    • 2
    Email author
  • Ilker Yagci
    • 2
  • Esra Giray
    • 2
  1. 1.Marmara University School of MedicineIstanbulTurkey
  2. 2.Department of Physical Medicine and Rehabilitation and AlgologyMarmara University School of MedicinePendikTurkey

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