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Clinical management of patients with hip and knee osteoarthritis: patient satisfaction with treatment switch

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Abstract

Hip and knee osteoarthritis (OA) is a common cause of disability, with great quality of life and economic impact, hence the need for effective treatment. Patient satisfaction with treatment is a measure of therapeutic effectiveness and may be used to assess treatment switch in OA patients. A 3-month multicenter, prospective, epidemiologic, non-interventional study was conducted in patients with hip and/or knee OA to assess therapeutic efficacy in patients requiring treatment switch due to lack of effectiveness and/or tolerability in primary care settings. Therapeutic effectiveness was assessed by patient satisfaction using the osteoARthritis Treatment Satisfaction (ARTS) scale. The 3-month disease change [by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and a pain visual analog scale (VAS)] and its correlation with treatment satisfaction were also assessed, as well as patient gastrointestinal (GI) and cardiovascular (CV) profiles. 5,976 patients were analyzed (mean age 68.8 years, 65.1 % female). 67 and 61.8 % showed high GI and CV risk, respectively. The proportion of patients on acetaminophen treatment during the study decreased from 74.8 % at baseline to 23.9 %, while the proportion on non-steroidal anti-inflammatory drugs (NSAIDs) increased from 59.8 to 85.8 %. At 3 months, the standardized (0–100) overall ARTS score increased from 57.7 to 71.6 (p < 0.0001), while disease severity decreased. There was a significant (p < 0.0001) negative association between the ARTS, and the WOMAC and VAS scores. Treatment switching from acetaminophen to NSAIDs as a consequence of poor effectiveness and/or tolerability resulted in increased patient satisfaction with treatment and lower OA severity.

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Acknowledgments

We thank Dr. Almudena Pardo Mateos for writing the first draft of the manuscript. This service was funded by Pfizer S.L.U. We thank Dr. Javier Rejas (Pfizer) for his many helpful comments on the manuscript.

Conflict of interest

Pfizer S.L.U. funded the study. Sergio Giménez, Jesús Iturralde Iriso, and Leovigildo Ginel Mendoza declare no conflict of interests. Beatriz Armada and Bárbara Fernández are Pfizer employees.

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Authors and Affiliations

  1. UGC Limonar, C/ Republica Argentina s/n, 29016, Málaga, Spain

    Sergio Gimenez

  2. Medical Department, Pfizer, S.L.U., Alcobendas, Madrid, Spain

    Beatriz Armada & Bárbara Fernández-Morales

  3. Centro De Salud Casco Viejo, Vitoria, Álava, Spain

    Jesús Iturralde Iriso

  4. UGC Ciudad Jardín De Málaga, Málaga, Spain

    Leovigildo Ginel Mendoza

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  1. Sergio Gimenez
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Correspondence to Sergio Gimenez.

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Gimenez, S., Armada, B., Iriso, J.I. et al. Clinical management of patients with hip and knee osteoarthritis: patient satisfaction with treatment switch. Rheumatol Int 34, 823–832 (2014). https://doi.org/10.1007/s00296-013-2918-6

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