Rheumatology International

, Volume 34, Issue 6, pp 793–801 | Cite as

Candidate’s single-nucleotide polymorphism predictors of treatment nonresponse to the first anti-TNF inhibitor in ankylosing spondylitis

  • Ruxandra Schiotis
  • Alejandra Sánchez
  • Alejandro Escudero
  • Nerea Bartolomé
  • Magdalena Szczypiorska
  • Pilar Font
  • Antonio Martínez
  • Diego Tejedor
  • Marta Artieda
  • Juan Mulero
  • Anca Buzoianu
  • Eduardo Collantes-Estévez
Original Article

Abstract

The objective of this study is to identify single-nucleotide polymorphisms (SNPs) predictors of treatment nonresponse to the first anti-TNF-alpha agent in ankylosing spondylitis (AS). Patients were classified as “nonresponders” if they failed to achieve improvement ≥50 % of the initial BASDAI. We selected candidate SNPs previously reported, associated with susceptibility or pathogenesis of AS and with other spondylarthropaties (SpAs). The predictors of nonresponse were modeled with multiple logistic regression. The predictive power of the genetic model of nonresponse to treatment was tested with AUC-ROC. One hundred and twenty-one (121) AS patients fulfilled the inclusion criteria. Of the candidate SNPs tested for association with treatment effectiveness, five independent predictors were identified: rs917997, rs755622, rs1800896, rs3740691, and rs1061622. The genetic model of nonresponse to treatment had a predictive power of 0.77 (95 % CI 0.68–0.86). Our study identified several polymorphisms which could be the useful genetic biomarkers in predicting nonresponse to anti-TNF-alpha therapy.

Keywords

Ankylosing spondylitis Anti-TNF-alpha agents SNPs Treatment response 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Ruxandra Schiotis
    • 1
    • 2
  • Alejandra Sánchez
    • 3
  • Alejandro Escudero
    • 2
  • Nerea Bartolomé
    • 4
  • Magdalena Szczypiorska
    • 4
  • Pilar Font
    • 2
  • Antonio Martínez
    • 4
  • Diego Tejedor
    • 4
  • Marta Artieda
    • 4
  • Juan Mulero
    • 3
  • Anca Buzoianu
    • 1
  • Eduardo Collantes-Estévez
    • 2
  1. 1.Department of Pharmacology“Iuliu Hatieganu” University of Medicine and PharmacyCluj-NapocaRomania
  2. 2.Department of Rheumatology, “Reina Sofia” Universitary Hospital, Instituto Maimónides de Investigación Biomedica de Córdoba (IMIBIC)University of CórdobaCórdobaSpain
  3. 3.Department of Rheumatology“Puerta de Hierro Majadahonda” University HospitalMadridSpain
  4. 4.Department of R+DProgenika Biopharma SADerioSpain

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