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Therapeutic potential of SIGIRR in systemic lupus erythematosus

Rheumatology International volume 33, pages 1917–1921 (2013)Cite this article

Abstract

Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. Different from other typical IL-1R superfamily members, SIGIRR seems to exert negatively modulates in immune responses. Several previous studies demonstrated that SIGIRR influences chronic inflammatory or autoimmune diseases, such as intestinal inflammation, rheumatoid arthritis and psoriatic arthritis. Recent work has explored the role of SIGIRR in systemic lupus erythematosus (SLE), for example, the role of SIGIRR protects the mice from hydrocarbon oil-induced lupus has been reported. These results indicate that SIGIRR may represent a novel target for the treatment of SLE. In this review, we will discuss the SIGIRR and the therapeutic potential of modulating the pathway in SLE.

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Acknowledgments

This work was supported by grants from the key program of National Natural Science Foundation of China (30830089, 81102192), the Specialized Research Fund for the Doctoral Program of Higher Education of China (20070366002) and Anhui Provincial Natural Science Foundation (11040606M183).

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Chao Wang, Chen-Chen Feng, Hai-Feng Pan, De-Guang Wang & Dong-Qing Ye

  2. Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100037, China

    Chao Wang

  3. Anhui Provincial Laboratory Of Population Health and Major Disease Screening and Diagnosis, Anhui Medical University, Hefei, China

    Chen-Chen Feng, Hai-Feng Pan, De-Guang Wang & Dong-Qing Ye

  4. Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

    De-Guang Wang

Authors
  1. Chao Wang
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  2. Chen-Chen Feng
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  3. Hai-Feng Pan
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  4. De-Guang Wang
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  5. Dong-Qing Ye
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Corresponding author

Correspondence to Dong-Qing Ye.

Additional information

Chao Wang and Chen-Chen Feng are contributed equally to this work and should be considered as co-first authors.

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Wang, C., Feng, CC., Pan, HF. et al. Therapeutic potential of SIGIRR in systemic lupus erythematosus. Rheumatol Int 33, 1917–1921 (2013). https://doi.org/10.1007/s00296-013-2733-0

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  • DOI: https://doi.org/10.1007/s00296-013-2733-0

Keywords

  • SIGIRR
  • Therapeutic target
  • Systemic lupus erythematosus
  • Lupus nephritis
  • Neuropsychiatric systemic lupus erythematosus