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Is there an association between Ro52/TRIM21 antibodies and rheumatoid factor in systemic sclerosis?

Rheumatology International volume 34, pages 425–427 (2014)Cite this article

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References

  1. Peene I, Meheus L, De Keyser S, Humbel R, Veys EM, De Keyser F (2002) Anti-Ro52 reactivity is an independent and additional serum marker in connective tissue disease. Ann Rheum Dis 61(10):929–933

    Article  CAS  PubMed  Google Scholar 

  2. Hudson M, Pope J, Mahler M, Tatibouet S, Steele R, Baron M, Canadian Scleroderma Research Group (CSRG), Fritzler M (2012) Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis. Arthritis Res Ther 14(2):R50

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Schulte-Pelkum J, Fritzler M, Mahler M (2009) Latest update on the Ro/SS-A autoantibody system. Autoimmun Rev 8(7):632–637

    Article  CAS  PubMed  Google Scholar 

  4. Takahata M, Bohgaki M, Tsukiyama T, Kondo T, Asaka M, Hatakeyama S (2008) Ro52 functionally interacts with IgG1 and regulates its quality control via the ERAD system. Mol Immunol 45(7):2045–2054

    Article  CAS  PubMed  Google Scholar 

  5. Retamozo S, Akasbi M, Brito-Zeron P, Bosch X, Bove A, Perez-de-Lis M, Jimenez I, Soto-Cardenas MJ, Gandia M, Diaz-Lagares C, Vinas O, Siso A, Perez-Alvarez R, Yague J, Ramos-Casals M (2012) Anti-Ro52 antibody testing influences the classification and clinical characterisation of primary Sjogren’s syndrome. Clin Exp Rheumatol 30(5):686–692

    PubMed  Google Scholar 

  6. Dugar M, Cox S, Limaye V, Gordon TP, Roberts-Thomson PJ (2010) Diagnostic utility of anti-Ro52 detection in systemic autoimmunity. Postgrad Med J 86(1012):79–82

    Article  PubMed  Google Scholar 

  7. Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Yazawa N, Tamaki K (2004) Rheumatoid factor isotypes and anti-agalactosyl IgG antibodies in systemic sclerosis. Br J Dermatol 151(4):803–808

    Article  CAS  PubMed  Google Scholar 

  8. Mimura Y, Ihn H, Jinnin M, Asano Y, Yamane K, Tamaki K (2005) Clinical and laboratory features of scleroderma patients developing skeletal myopathy. Clin Rheumatol 24(2):99–102

    Article  PubMed  Google Scholar 

  9. Ueda-Hayakawa I, Hasegawa M, Kumada S, Tanaka C, Komura K, Hamaguchi Y, Takehara K, Fujimoto M (2010) Usefulness of anti-cyclic citrullinated peptide antibody and rheumatoid factor to detect rheumatoid arthritis in patients with systemic sclerosis. Rheumatology (Oxford) 49(11):2135–2139

    Article  CAS  Google Scholar 

  10. Pakozdi A, Nihtyanova S, Moinzadeh P, Ong VH, Black CM, Denton CP (2011) Clinical and serological hallmarks of systemic sclerosis overlap syndromes. J Rheumatol 38(11):2406–2409

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The Canadian Scleroderma Research Group (CSRG) is funded by the Canadian Institutes of Health Research (CIHR) (grant #FRN 83518), the Scleroderma Society of Canada and its provincial Chapters, Scleroderma Society of Ontario, Sclérodermie Québec, Cure Scleroderma Foundation, INOVA Diagnostics Inc. (San Diego, CA), Dr. Fooke Laboratorien GmbH (Neuss, Germany), Euroimmun (Lubeck, Germany), Mikrogen GmbH (Neuried, Germany), Fonds de la recherche en santé du Québec (FRSQ), the Canadian Arthritis Network (CAN), and the Lady Davis Institute of Medical Research of the Jewish General Hospital, Montreal, QC. The CSRG has also received eductional grants from Pfizer and Actelion pharmaceuticals.

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Authors and Affiliations

  1. Division of Rheumatology, King George Medical College, Lucknow, India

    Sonal Mehra

  2. Division of Rheumatology, Lady Davis Institute, Jewish General Hospital, Montréal, QC, Canada

    Marie Hudson & Murray Baron

  3. INOVA Diagnostics, Inc., San Diego, CA, USA

    Michael Mahler

  4. Faculty of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada

    Marvin Fritzler

Authors
  1. Sonal Mehra
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  2. Marie Hudson
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  3. Michael Mahler
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  4. Murray Baron
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  5. Marvin Fritzler
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Canadian Scleroderma Research Group

Corresponding author

Correspondence to Marie Hudson.

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The Investigators of the Canadian Scleroderma Research Group is given in “Appendix”.

Appendix: Investigators of the Canadian Scleroderma Research Group

Appendix: Investigators of the Canadian Scleroderma Research Group

J. Pope, London, Ontario; M. Baron, Montreal, Quebec; J. Markland, Saskatoon, Saskatchewan; D. Robinson, Winnipeg, Manitoba; N. Jones, Edmonton, Alberta; N. Khalidi, Hamilton, Ontario; P. Docherty, Moncton, New Brunswick; E. Kaminska, Hamilton, Ontario; A. Masetto, Sherbrooke, Quebec; E. Sutton, Halifax, Nova Scotia; J-P. Mathieu, Montreal, Quebec; M. Hudson, Montreal, Quebec; S. Ligier, Montreal, Quebec; T. Grodzicky, Montreal, Quebec; S. LeClercq, Calgary, Alberta; C. Thorne, Newmarket, Ontario; G. Gyger, Montreal, Quebec; D. Smith, Ottawa, Ontario; P. R. Fortin, Quebec, Quebec; M. Fritzler, Advanced Diagnostics Laboratory, Calgary, Alberta.

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Mehra, S., Hudson, M., Mahler, M. et al. Is there an association between Ro52/TRIM21 antibodies and rheumatoid factor in systemic sclerosis?. Rheumatol Int 34, 425–427 (2014). https://doi.org/10.1007/s00296-013-2728-x

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  • DOI: https://doi.org/10.1007/s00296-013-2728-x

Keywords

  • Rheumatoid Factor
  • Rheumatoid Factor Titer
  • INOVA Diagnostics
  • Systemic Autoimmune Rheumatic Autoimmune Disease
  • Bead Immunoassay