Rheumatology International

, Volume 34, Issue 2, pp 285–286 | Cite as

MicroRNA-223: a double-edged sword in rheumatoid arthritis

  • Shih-Yao ChenEmail author
Letter to the Editor


Increased expression of microRNA-223 (miR-223) has been demonstrated in rheumatoid arthritis (RA) patients. Two research teams focus recently on the underlying mechanisms mediated by miR-223 but two stories are developed in opposite ways.


Rheumatoid Arthritis Patient Osteoclast Differentiation Human Peripheral Blood Mononuclear Cell Rheumatoid Arthritis Synovium Clinical Rheumatoid Arthritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Conflict of interest



  1. 1.
    Li YT, Chen SY, Wang CR, Liu MF, Lin CC, Jou IM et al (2012) Brief report: amelioration of collagen-induced arthritis in mice by lentivirus-mediated silencing of microRNA-223. Arthritis Rheum 64:3240–3245PubMedCrossRefGoogle Scholar
  2. 2.
    Shibuya H, Nakasa T, Adachi N, Nagata Y, Ishikawa M, Deie M et al (2012) Overexpression of microRNA-223 in rheumatoid arthritis synovium controls osteoclast differentiation. Mod Rheumatol (Epub ahead of print)Google Scholar
  3. 3.
    Nakamachi Y, Kawano S, Takenokuchi M, Nishimura K, Sakai Y, Chin T et al (2009) MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum 60:1294–1304PubMedCrossRefGoogle Scholar
  4. 4.
    Murata K, Yoshitomi H, Tanida S, Ishikawa M, Nishitani K, Ito H et al (2010) Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 12:R86PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Fulci V, Scappucci G, Sebastiani GD, Giannitti C, Franceschini D, Meloni F et al (2010) MiR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis. Hum Immunol 71:206–211PubMedCrossRefGoogle Scholar
  6. 6.
    Sugatani T, Hruska KA (2009) Impaired micro-RNA pathways diminish osteoclast differentiation and function. J Biol Chem 284:4667–4678PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyNational Cheng Kung University Medical CollegeTainanTaiwan

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