Rheumatology International

, Volume 34, Issue 6, pp 759–762 | Cite as

Mediterranean diet intervention for patients with hyperuricemia: a pilot study

  • M. Chatzipavlou
  • G. Magiorkinis
  • L. Koutsogeorgopoulou
  • D. KassimosEmail author
Short Communication


Dietary interventions have been suggested to be a safe cost-efficient way to control hyperuricemia. The aim of the study is to assess the potential of mediterranean diet as intervention to control the level of urate in patients with hyperuricemia in a small sample of patients. Patients with asymptomatic hyperuricemia were recruited from outpatient clinics and were enrolled into personal Mediterranean diet–based programs. Body mass index (BMI), serum urate, lipid profile and indirect calorimetry were measured at the beginning and then monthly for the first 3 months and then at the sixth month. At the same time, patients’ compliance with the Mediterranean diet was assessed by a formal interview and standard questionnaire. Only six out of twelve patients managed to complete the diet (dropout rate 50 %). Their BMI remained constant during the trial period in the level of 1st degree obesity (BMI = 31.46). The mean value of serum urate at the beginning of the study was 9.12 mg/dl. After the first month, there was a reduction in urate by 20 % with mean urate at 6.92 mg/dl. The second, third and sixth month mean urate levels were 6.32, 6.1 and 6.4 mg/dl, respectively. The effect of the mediterranean diet was rapid at the first month and remained constant throughout the dietary intervention, suggesting that it might have a clinically significant effect on urate level thus providing a cost-efficient and safe alternative to pharmaceutical intervention as first-line treatment of hyperuricemia.


Hyperuricemia Mediterranean diet intervention Pilot study 



M. C., L. K. and D. K. designed and conducted research. G. M. performed statistical analyses. All the authors contributed in the writing of the paper.

Conflict of interest

The authors declare no conflicts of interest.


  1. 1.
    Willett WC, Sacks F, Trichopoulou A, Drescher G, Ferro-Luzzi A, Helsing E et al (1995) Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 61:1402S–1406SPubMedGoogle Scholar
  2. 2.
    Sofi F, Abbate R, Gensini GF, Casini A (2010) Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr 92:1189–1196PubMedCrossRefGoogle Scholar
  3. 3.
    Fam AG (2005) Gout: excess calories, purines, and alcohol intake and beyond. Response to a urate-lowering diet. J Rheumatol 32:773–777PubMedGoogle Scholar
  4. 4.
    Choi HK, Liu S, Curhan G (2005) Intake of purine-rich foods, protein, and dairy products and relationship to serum levels of uric acid: the third national health and nutrition examination survey. Arthr Rheum 52:283–289CrossRefGoogle Scholar
  5. 5.
    Matalas A-L (2001) The mediterranean diet. Constituents and health promotion. Taylor and Francis Group, UKGoogle Scholar
  6. 6.
    Mahan K, Escott-Stump S (2003) Food, nutrition and diet therapy, 11th edn. Saunders, pp 318–336, 342–347Google Scholar
  7. 7.
    Merilainen PT (1987) Metabolic monitor. Int J Clin Monit Comput 4:167–177PubMedCrossRefGoogle Scholar
  8. 8.
    Panagiotakos DB, Pitsavos C, Stefanadis C (2006) Dietary patterns: a mediterranean diet score and its relation to clinical and biological markers of cardiovascular disease risk. Nutr Metab Cardiovasc Dis 16:559–568PubMedCrossRefGoogle Scholar
  9. 9.
    StataCorp (2003) Stata Statistical Software: release 8.0. Stata Corporation, College Station, TXGoogle Scholar
  10. 10.
    Babio N, Bullo M, Salas-Salvado J (2009) Mediterranean diet and metabolic syndrome: the evidence. Public Health Nutr 12:1607–1617PubMedCrossRefGoogle Scholar
  11. 11.
    Borges RL, Ribeiro AB, Zanella MT, Batista MC (2010) Uric acid as a factor in the metabolic syndrome. Curr Hypertens Rep 12:113–119PubMedCrossRefGoogle Scholar
  12. 12.
    Chrysohoou C, Skoumas J, Pitsavos C, Masoura C, Siasos G, Galiatsatos N, Psaltopoulou T, Mylonakis C, Margazas A, Kyvelou S, Mamatas S, Panagiotakos D, Stefanadis C (2011) Long-term adherence to the mediterranean diet reduces the prevalence of hyperuricaemia in elderly individuals, without known cardiovascular disease: the Ikaria study. Maturitas 70(1):58–64PubMedCrossRefGoogle Scholar
  13. 13.
    Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I, Golan R, Fraser D, Bolotin A, Vardi H et al (2008) Dietary intervention randomized controlled trial (DIRECT) group. Weight loss with a low-carbohydrate, mediterranean, or low-fat diet. N Engl J Med 359(3):229–241PubMedCrossRefGoogle Scholar
  14. 14.
    Bautista-Castano I, Molina-Cabrillana J, Montoya-Alonso JA, Serra-Majem L (2004) Variables predictive of adherence to diet and physical activity recommendations in the treatment of obesity and overweight, in a group of Spanish subjects. Int J Obes Relat Metab Disord 28:697–705PubMedCrossRefGoogle Scholar
  15. 15.
    Ioannides JPA (2005) Why most of published research findings are false. PLoS Med 2(8):e124Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • M. Chatzipavlou
    • 1
  • G. Magiorkinis
    • 2
  • L. Koutsogeorgopoulou
    • 3
  • D. Kassimos
    • 4
    Email author
  1. 1.Nutrition Department401 General Military Hospital of AthensAthensGreece
  2. 2.Department of Zoology, St. Cross CollegeUniversity of OxfordOxfordUK
  3. 3.Department of PathophysiologyGeneral Hospital “Laiko”AthensGreece
  4. 4.Rheumatology Unit401 General Military Hospital of AthensAthensGreece

Personalised recommendations