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Interstitial lung disease in clinically amyopathic dermatomyositis (CADM) patients: a retrospective study of 41 Chinese Han patients

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Abstract

To study the clinical features and associated risk factors of interstitial lung disease (ILD) in clinically amyopathic dermatomyositis (CADM) in Chinese patients. Forty-one Chinese Han patients with a diagnosis of CADM in West China Hospital from August 2008 to 2011 were retrospectively analyzed. The prevalence of ILD in CADM patients is 60.98 %, in which 26.83 % for acute/subacute interstitial pneumonia (A/SIP) and 34.15 % for chronic interstitial pneumonia (CIP). Mortality of A/SIP is 63.64 %, with a 6-month survival rate of 54.50 %. Levels of erythrocyte sedimentation rate, serum ferritin, alanine aminotransferase, aspartate aminotransferase, creatine kinase, lactate dehydrogenase, hydroxybutyric dehydrogenase, and immunoglobulin A (IgA) are higher in CADM-ILD patients than CADM patients without ILD. Levels of serum ALB and lymphocyte count in peripheral blood are significant lower in A/SIP than in CIP group. Sign of ground glass opacities in high-resolution computed tomography (HRCT) images is more common in A/SIP group, and diffusion function is worse in these patients compared with CIP group. The prevalence of ILD in Chinese CADM patients is strikingly high, and A/SIP is a major cause of death in CADM patients. Laboratory findings combined with HRCT examination and pulmonary function tests can provide valuable predictive information of ILD or A/SIP in CADM patients.

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Acknowledgments

The work was partially supported by NSFC (Natural Science Foundation of China) grant 30830094, 30972678 to Dr. Guixiu Shi and 30801028, 81172870 to Dr. Bing Yan.

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Authors and Affiliations

  1. Department of Rheumatology, West China Hospital, Sichuan University, No. 37 Wainan Guoxue Lane, Chengdu, 610041, China

    Yuan Liu, Bing Yan & Guixiu Shi

  2. Department of Rheumatology, The First Affiliated Hospital, Xiamen University, No. 55, Zhenhai Road, Xiamen, 361003, China

    Yuechi Sun

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  1. Yuechi Sun
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  2. Yuan Liu
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  3. Bing Yan
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  4. Guixiu Shi
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Correspondence to Bing Yan or Guixiu Shi.

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Yuechi Sun and Yuan Liu contributed equally to this study.

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Sun, Y., Liu, Y., Yan, B. et al. Interstitial lung disease in clinically amyopathic dermatomyositis (CADM) patients: a retrospective study of 41 Chinese Han patients. Rheumatol Int 33, 1295–1302 (2013). https://doi.org/10.1007/s00296-012-2545-7

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  • DOI: https://doi.org/10.1007/s00296-012-2545-7

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