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Rheumatology International

, Volume 33, Issue 5, pp 1229–1232 | Cite as

The levels of β-thromboglobulin in female rheumatoid arthritis patients as activation criteria

  • Cumali KaratoprakEmail author
  • Seyit Uyar
  • Gul Babacan Abanonu
  • Seval Masatlioglu Pehlevan
  • Nalan Okuroglu
  • Refik Demirtunc
Original Article

Abstract

The activation of the platelets plays a key role in the formation of thrombosis. The variables such as mean platelet volume, platelet factor 4 and β-thromboglobulin have been used in the demonstration of the platelet activation. However, when the literature was reviewed, there was not found any study investigating the level of β-thromboglobulin in patients with rheumatoid arthritis. Our goal is to evaluate the β-thromboglobulin levels together with mean platelet volume in patients with arthritis. This study is a clinical study which has a control group that has been designed prospectively, and in this study, Rheumatology Outpatient Clinic follow-up patients with rheumatoid arthritis and healthy control group were studied. All patients and healthy volunteers were examined β-thromboglobulin and mean platelet volume. Twenty-two patients with rheumatoid arthritis and 21 healthy volunteers participated in the study. β-Thromboglobulin mean was found as 98.00 ± 60.49 ng/mL in rheumatoid arthritis group and it was 62.38 ± 30.41 ng/mL in healthy control group. The differences between these groups were significant in terms of the levels of β-thromboglobulin (p = 0.02). We found significant differences between the groups in terms of mean platelet volume (p = 0.049). In this study, the level of β-thromboglobulin was found significantly higher in patients with rheumatoid arthritis, which is a chronic inflammatory disease. This result could be an indicator, such as platelet activation in patients with rheumatoid arthritis, or it may be a helper marker in the follow-up and treatment of developing cardiovascular risk.

Keywords

Rheumatoid arthritis Mean platelet volume β-Thromboglobulin Platelet function Atherosclerosis 

Notes

Conflict of interest

We declare there is no conflict of interest.

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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Cumali Karatoprak
    • 1
    Email author
  • Seyit Uyar
    • 2
  • Gul Babacan Abanonu
    • 2
  • Seval Masatlioglu Pehlevan
    • 2
    • 3
  • Nalan Okuroglu
    • 2
  • Refik Demirtunc
    • 2
  1. 1.Faculty of Medicine, Internal Medicine ClinicBezmialem Vakif UniversityFatihTurkey
  2. 2.Internal Medicine ClinicHaydarpasa Numune Treatment and Research HospitalUskudarTurkey
  3. 3.Rhematology ClinicHaydarpasa Numune Treatment and Research HospitalUskudarTurkey

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