Rheumatology International

, Volume 33, Issue 5, pp 1229–1232 | Cite as

The levels of β-thromboglobulin in female rheumatoid arthritis patients as activation criteria

  • Cumali KaratoprakEmail author
  • Seyit Uyar
  • Gul Babacan Abanonu
  • Seval Masatlioglu Pehlevan
  • Nalan Okuroglu
  • Refik Demirtunc
Original Article


The activation of the platelets plays a key role in the formation of thrombosis. The variables such as mean platelet volume, platelet factor 4 and β-thromboglobulin have been used in the demonstration of the platelet activation. However, when the literature was reviewed, there was not found any study investigating the level of β-thromboglobulin in patients with rheumatoid arthritis. Our goal is to evaluate the β-thromboglobulin levels together with mean platelet volume in patients with arthritis. This study is a clinical study which has a control group that has been designed prospectively, and in this study, Rheumatology Outpatient Clinic follow-up patients with rheumatoid arthritis and healthy control group were studied. All patients and healthy volunteers were examined β-thromboglobulin and mean platelet volume. Twenty-two patients with rheumatoid arthritis and 21 healthy volunteers participated in the study. β-Thromboglobulin mean was found as 98.00 ± 60.49 ng/mL in rheumatoid arthritis group and it was 62.38 ± 30.41 ng/mL in healthy control group. The differences between these groups were significant in terms of the levels of β-thromboglobulin (p = 0.02). We found significant differences between the groups in terms of mean platelet volume (p = 0.049). In this study, the level of β-thromboglobulin was found significantly higher in patients with rheumatoid arthritis, which is a chronic inflammatory disease. This result could be an indicator, such as platelet activation in patients with rheumatoid arthritis, or it may be a helper marker in the follow-up and treatment of developing cardiovascular risk.


Rheumatoid arthritis Mean platelet volume β-Thromboglobulin Platelet function Atherosclerosis 


Conflict of interest

We declare there is no conflict of interest.


  1. 1.
    Schellekens GA, de Jong BA, van den Hoogen FH, van de Putte LB, van Venrooij WJ (1998) Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-spesific autoantibodies. JClin İnvest 101:273–281CrossRefGoogle Scholar
  2. 2.
    Mevorach D, Paget SA (2000) Rheumatoid arthritis. In: Paget SA, Gibofsky A, Beary JF III (eds) Manuel of rheumatology and outpatient orthopedic disorders, 4th edn. Lippincott Williams & Wilkins, Philadelphia, pp 192–229Google Scholar
  3. 3.
    Hurd ER (1979) Extraarticular manifestations of RA. Semin Arthritis Rheum 8(3):151–176PubMedCrossRefGoogle Scholar
  4. 4.
    Gasparyan AY, Stavropoulos-Kalinoglou A, Mikhailidis DP, Douglas KM, Kitas GD (2011) Platelet function in rheumatoid arthritis: arthritic and cardiovascular implications. Rheumatol Int 31(2):153–164PubMedCrossRefGoogle Scholar
  5. 5.
    Bacon PA, Stevens RJ, Carruthers DM, Young SP, Kitas GD (2002) Accelerated atherogenesis in autoimmune rheumatic diseases. Autoimmun Rev 1(6):338–347PubMedCrossRefGoogle Scholar
  6. 6.
    Manzi S, Wasko MC (2000) Inflammation-mediated rheumatic diseases and atherosclerosis. Ann Rheum Dis 59(5):321–325PubMedCrossRefGoogle Scholar
  7. 7.
    Haskard DO (2004) Accelerated atherosclerosis in inflammatory rheumatic diseases. Scand J Rheumatol 33(5):281–292PubMedCrossRefGoogle Scholar
  8. 8.
    Meyer O (2001) Atherosclerosis and connective tissue diseases. Jt Bone Spine 68(6):564–575CrossRefGoogle Scholar
  9. 9.
    Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, Jordanova N, Christ G, Thalhammer R, Huber K, Sunder-Plassmann R (2002) Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 117(2):399–404PubMedCrossRefGoogle Scholar
  10. 10.
    Begg GS, Pepper DS, Chesterman CN, Morgan FJ (1978) Complete covalent structure of human β-thromboglobulin. Am Chem Soc 17(9):1739–1744Google Scholar
  11. 11.
    Zahavi J, Kakkar VV (1980) β-Thromboglobulin—a specific marker of in vivo platelet release reaction. Thromb Haemost 44(1):23–29PubMedGoogle Scholar
  12. 12.
    Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS et al (1988) The American Rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31(3):315–324PubMedCrossRefGoogle Scholar
  13. 13.
    Dalby Kristensen S, Milner PC, Martin JF (1988) Bleeding time and platelet volume in acute myocardial infarction—a 2 year follow-up study. Thromb Haemost 59(3):353–356PubMedGoogle Scholar
  14. 14.
    Yazici S, Yazici M, Erer B, Erer B, Calik Y, Ozhan H, Ataoglu S (2010) The platelet indices in patients with rheumatoid arthritis: mean platelet volume reflects disease activity. Platelets 21(2):122–125PubMedCrossRefGoogle Scholar
  15. 15.
    Gasparyan AY, Stavropoulos-Kalinoglou A, Toms TE, Douglas KMJ, Kitas GD (2010) Association of mean platelet volume with hypertension in rheumatoid arthritis. Inflamm Allergy Drug Targets 9(1):45–50PubMedCrossRefGoogle Scholar
  16. 16.
    Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, Kiraz S, Ertenli I, Calguneri M (2008) Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 75(3):291–294PubMedCrossRefGoogle Scholar
  17. 17.
    Makay B, Türkyilmaz Z, Unsal E (2009) Mean platelet volume in children with familial mediterranen fever. Clin Rheumatol 28(8):975–978PubMedCrossRefGoogle Scholar
  18. 18.
    Warkentin TE, Kelton JG (2003) Platelet life cycle: quantitative disorders. In: Handin RI, Lux SE, Stossel TP (eds) Blood, principles and practise of hematology, 2nd edn. Lippincott Williams and Wilkins, Philadelphia, pp 984–1032Google Scholar
  19. 19.
    Ekdahl KN, Bengtsson AA, Andersson J, Elgue G, Rönnblom L, Sturfelt G, Nilsson B (2004) Thrombotic disease in systemic lupus erythematosus is associated with a maintained systemic platelet activation. Br J Haematol 125(1):74–78PubMedCrossRefGoogle Scholar
  20. 20.
    Abramson DB, Amin A (2002) Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage. Rheumatology 41(9):972–980PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Cumali Karatoprak
    • 1
    Email author
  • Seyit Uyar
    • 2
  • Gul Babacan Abanonu
    • 2
  • Seval Masatlioglu Pehlevan
    • 2
    • 3
  • Nalan Okuroglu
    • 2
  • Refik Demirtunc
    • 2
  1. 1.Faculty of Medicine, Internal Medicine ClinicBezmialem Vakif UniversityFatihTurkey
  2. 2.Internal Medicine ClinicHaydarpasa Numune Treatment and Research HospitalUskudarTurkey
  3. 3.Rhematology ClinicHaydarpasa Numune Treatment and Research HospitalUskudarTurkey

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