In vivo measurements of blood flow and bone metabolism in osteoarthritis
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With increasing age, there may be a decrease in femoral blood flow. In some patients, this may result in local ischaemia, which subsequently may lead to local degenerative changes. Consequently, bone blood flow may play an important role in the aetiology of osteoarthritis of the hip. Little is known about bone blood flow in the femoral head of patients with advanced hip osteoarthritis. The purpose of this study was to evaluate bone blood flow and metabolism in vivo in patients with osteoarthritis of the hip. Ten patients with symptomatic osteoarthritis of the hip were enrolled prospectively. Femoral bone blood flow and metabolism were measured using positron emission tomography together with H 2 15 O and [18F]fluoride, respectively. Blood flow was 0.054 ± 0.032 mL cm−3 min−1 and 0.041 ± 0.012 mL cm−3 min−1 in symptomatic and contralateral femoral heads, respectively (p = 0.435). The net flux of fluoride from plasma to bone mineral (K i ) was significantly (p = 0.027) higher in the femoral head of the osteoarthritic hip (0.022 ± 0.012 mL cm−3 min−1) than in that of the contralateral hip (0.007 ± 0.005 mL cm−3 min−1). This study showed significant increase in bone metabolism in the proximal femur of patients with symptomatic osteoarthritis of the hip joint. There was no evidence of decreased blood flow.
KeywordsHip Osteoarthritis Bone metabolism Blood flow PET
Conflict of interest
None of the authors declare a conflict of interest.
The study protocol was approved by the Medical Ethics Review Committee of the VU University Medical Centre. All patients gave written informed consent prior to scanning.
- 3.Bloomfield SA, Hogan HA, Delp MD (2002) Decreases in bone blood flow and bone material properties in aging Fischer-344 rats. Clin Orthop Relat Res (396):248–257Google Scholar
- 9.Hawkins RA, Hoh KC, Phelps ME (1996) PET imaging of the skeletal system. In: Sandler MP, Coleman RE, Wackers FJTh et al (eds) Diagnostic nuclear medicine. Williams & Wilkins, Baltimore, p 725Google Scholar
- 21.Messa C, Goodman WG, Hoh CK, Choi Y, Nissenson AR, Salusky IB, Phelps ME, Hawkins RA (1993) Bone metabolic activity measured with positron emission tomography and [18F]fluoride ion in renal osteodystrophy: correlation with bone histomorphometry. J Clin Endocrinol Metab 77:949–955PubMedCrossRefGoogle Scholar
- 23.Nakamura F, Fujioka M, Takahashi KA, Ueshima K, Arai Y, Imahori Y, Itani K, Nishimura T, Kubo T (2005) Evaluation of the hemodynamics of the femoral head compared with the ilium, femoral neck and femoral intertrochanteric region in healthy adults: measurement with positron emission tomography (PET). Ann Nucl Med 19:549–555PubMedCrossRefGoogle Scholar
- 40.Whiteside LA, Lesker PA, Simmons DJ (1977) Measurement of regional bone and bone marrow blood flow in the rabbit using the hydrogen washout technique. Clin Orthop Relat Res (122):340–346Google Scholar