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Lack of association between polymorphisms of thrombogenic genes and disease susceptibility in rheumatoid arthritis

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Abstract

Rheumatoid arthritis (RA) is associated with increased mortality due to cardiovascular disease (CVD). Abnormalities in coagulation have been linked with CVD in general and RA population. The aim of our study is to determine whether particular single nucleotide polymorphisms thought to be involved in the regulation of coagulation are over-represented in patients with RA compared to controls. We compared the frequency of atherothrombotic polymorphisms (Factor V Leiden, fibrinogen G455A, prothrombin G20210A and plasminogen activator inhibitor 4G5G) in 322 RA patients [231 females, mean age 61.5 ± 12, median disease duration 10 years (IQR = 14)] with 441 local controls. No significant differences were observed in genotype or allele frequencies either between RA and controls or between the disease subgroups studied. Whereas these polymorphisms may be of importance at the level of individual patients, they are unlikely to be clinically important on a population basis.

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References

  1. Juhan-Vague I, Morange P, Christine Alessi M (1999) Fibrinolytic function and coronary risk. Curr Cardiol Rep 1:119–124

    Article  PubMed  CAS  Google Scholar 

  2. Wållberg-Jonsson S, Cederfelt M, Rantapää Dahlqvist S (2000) Hemostatic factors and cardiovascular disease in active rheumatoid arthritis: an 8 year followup study. J Rheumatol 27:71–75

    PubMed  Google Scholar 

  3. Ye Z, Liu EH, Higgins JP, Keavney BD, Lowe GD, Collins R, Danesh J (2006) Seven haemostatic gene polymorphisms in coronary disease: meta-analysis of 66,155 cases and 91,307 controls. Lancet 367:651–658

    Article  PubMed  CAS  Google Scholar 

  4. Iacoviello L, Burzotta F, Di Castelnuovo A, Zito F, Marchioli R, Donati M (1998) The 4G/5G polymorphism of the PAI-1-1 promoter gene and the risk of myocardial infarction: a meta-analysis. Thromb Haemost 80:1029–1030

    PubMed  CAS  Google Scholar 

  5. Green FR, Hamsten A, Blomback M (1993) The role of the fibrinogen genotype in determining plasma fibrinogen levels in the young survivors of myocardial infarction and healthy controls from Sweden. Thromb Haemost 70:915–920

    PubMed  CAS  Google Scholar 

  6. Arlestig L, Wållberg Jonsson S, Stegmayr B, Rantapää-Dahlqvist S (2007) Polymorphism of genes related to cardiovascular disease in patients with rheumatoid arthritis. Clin Exp Rheumatol 25:866–871

    PubMed  CAS  Google Scholar 

  7. Torres-Carrillo N, Torres-Carrillo NM, Martínez-Bonilla GE, Vázquez-Del Mercado M, Palafox-Sánchez CA, Oregón-Romero E, Bernard-Medina AG, Rangel-Villalobos H, Muñoz-Valle JF (2009) Plasminogen activator inhibitor-1 C/G polymorphism in relation to plasma levels in rheumatoid arthritis. Clin Exp Med 9:223–228

    Article  PubMed  CAS  Google Scholar 

  8. Arnett FC, Edwarthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315–324

    Article  PubMed  CAS  Google Scholar 

  9. Subrungruang I, Mungthin M, Chavalitshewinkoon-Petmitr P, Rangsin R, Naaglor T, Leelayoova S (2004) Evaluation of DNA extraction and PCR methods for detection of Enterocytozoon bieneusi in stool. J Clin Microbiol 42:3490–3494

    Article  PubMed  CAS  Google Scholar 

  10. Panoulas VF, Douglas KM, Smith JP, Metsios GS, Elisaf MS, Nightingale P, Kitas GD (2009) Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis. Clin Exp Hypertens 31:93–104

    Article  PubMed  CAS  Google Scholar 

  11. Douglas KMJ, Pace AV, Treharne GJ, Saratzis A, Nightingale P, Erb N, Banks MJ, Kitas GD (2005) Excess recurrent cardiac events in rheumatoid arthritis patients with acute coronary syndrome. Ann Rheum Dis 65:348–353

    Article  PubMed  Google Scholar 

  12. Torres-Carrillo N, Magdalena Torres-Carrillo N, Vázquez-Del Mercado M, Rangel-Villalobos H, Parra-Rojas I, Sánchez-Enríquez S, Francisco Muñoz-Valle J (2008) Distribution of –844 G/A and Hind III C/G PAI-1 polymorphisms and plasma PAI-1 levels in Mexican subjects: comparison of frequencies between populations. Clin Appl Thromb Hemost 14:220–226

    Article  PubMed  CAS  Google Scholar 

  13. Goodson NJ, Wiles NJ, Lunt M, Barrett EM, Silman AJ, Symmons DP (2002) Mortality in early inflammatory polyarthritis: cardiovascular mortality is increased in seropositive patients. Arthritis Rheum 48:2010–2019

    Article  Google Scholar 

  14. Turesson C, McClelland RL, Christianson TJ, Matteson EL (2006) Multiple extra-articular manifestations are associated with poor survival in patients with rheumatoid arthritis. Ann Rheum Dis 65:1533–1534

    Article  PubMed  CAS  Google Scholar 

  15. Lane DA, Grant PJ (2000) Role of hemostatic gene polymorphisms in venous and arterial thrombotic disease. Blood 95:1517–1532

    PubMed  CAS  Google Scholar 

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Acknowledgments

Dr Theodoros Dimitroulas has been supported by the Rheumatology Society of Northern Greece and the Hellenic Society for Rheumatology.

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Authors and Affiliations

  1. Department of Rheumatology, Dudley Group of Hospitals NHS Foundation Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, DY1 2HQ, UK

    Theodoros Dimitroulas, Karen M. J. Douglas, Jacqueline Smith, Vasilis F. Panoulas & George D. Kitas

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  1. Theodoros Dimitroulas
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  2. Karen M. J. Douglas
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  3. Jacqueline Smith
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  4. Vasilis F. Panoulas
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  5. George D. Kitas
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Corresponding author

Correspondence to George D. Kitas.

Additional information

The authors Theodoros Dimitroulas and Karen M. J. Douglas have equally contributed to this work and therefore share first authorship.

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Dimitroulas, T., Douglas, K.M.J., Smith, J. et al. Lack of association between polymorphisms of thrombogenic genes and disease susceptibility in rheumatoid arthritis . Rheumatol Int 33, 2429–2432 (2013). https://doi.org/10.1007/s00296-012-2392-6

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  • DOI: https://doi.org/10.1007/s00296-012-2392-6

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