Familial antiphospholipid syndrome presenting as bivessel arterial occlusion in a 17-year-old girl
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This article presents a case of a 17-year-old girl with primary antiphospholipid syndrome developing subacute signs of hand and leg ischaemia caused by radiologically verified radial and popliteal artery occlusion. She is successfully treated with a thrombolytic agent (alteplase) and recovers completely. Her laboratory results came positive for all three subtypes of antiphospholipid antibodies. This kind of antiphospholipid syndrome presentation is a very rare entity in itself. Shortly afterwards her mother is diagnosed with primary antiphospholipid syndrome as well. A familial form of antiphospholipid syndrome is suspected. Combination of a familial antiphospholipid syndrome presenting as bivessel arterial thrombosis is a unique case, to the best of our knowledge, never described in the literature before.
KeywordsFamilial antiphospholipid syndrome Child Peripheral arterial disease Thrombosis Aetiology Antibodies Antiphospholipid
Systemic lupus erythematosus
Catastrophic antiphospholipid syndrome
Low-molecular weight heparin
Deep vein thrombosis
Conflict of interest
The authors declare that they have no conflict of interest.
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