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Rheumatology International

, Volume 33, Issue 5, pp 1359–1362 | Cite as

Familial antiphospholipid syndrome presenting as bivessel arterial occlusion in a 17-year-old girl

  • Marija JelušićEmail author
  • Katarina Starčević
  • Mandica Vidović
  • Savko Dobrota
  • Kristina Potočki
  • Ljiljana Banfić
  • Branimir Anić
Short Communication

Abstract

This article presents a case of a 17-year-old girl with primary antiphospholipid syndrome developing subacute signs of hand and leg ischaemia caused by radiologically verified radial and popliteal artery occlusion. She is successfully treated with a thrombolytic agent (alteplase) and recovers completely. Her laboratory results came positive for all three subtypes of antiphospholipid antibodies. This kind of antiphospholipid syndrome presentation is a very rare entity in itself. Shortly afterwards her mother is diagnosed with primary antiphospholipid syndrome as well. A familial form of antiphospholipid syndrome is suspected. Combination of a familial antiphospholipid syndrome presenting as bivessel arterial thrombosis is a unique case, to the best of our knowledge, never described in the literature before.

Keywords

Familial antiphospholipid syndrome Child Peripheral arterial disease Thrombosis Aetiology Antibodies Antiphospholipid 

Abbreviations

APS

Antiphospholipid syndrome

aPL

Antiphospholipid

aCL

Anti-cardiolipin

β2-GPI

β2-glycoprotein I

LAC

Lupus anticoagulant

SLE

Systemic lupus erythematosus

CAPS

Catastrophic antiphospholipid syndrome

LWMH

Low-molecular weight heparin

ANA

Antinuclear antibodies

DVT

Deep vein thrombosis

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Marija Jelušić
    • 1
    Email author
  • Katarina Starčević
    • 1
  • Mandica Vidović
    • 1
  • Savko Dobrota
    • 2
  • Kristina Potočki
    • 2
  • Ljiljana Banfić
    • 3
  • Branimir Anić
    • 4
  1. 1.Division of Paediatric Rheumatology and Immunology, Department of PaediatricsUniversity Hospital Center ZagrebZagrebCroatia
  2. 2.Department of Diagnostic and Interventional RadiologyUniversity Hospital Center ZagrebZagrebCroatia
  3. 3.Department of Cardiovascular DiseaseUniversity Hospital Center ZagrebZagrebCroatia
  4. 4.Division of Immunology and Rheumatology, Department of Internal MedicineUniversity Hospital Center ZagrebZagrebCroatia

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