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QT dispersion and cardiac involvement in patients with juvenile idiopathic arthritis

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Abstract

Juvenile idiopathic arthritis (JIA) is the commonest cause of chronic inflammatory arthritis in childhood. Cardiac involvement as pericarditis, myocarditis and valvular disease is known to occur in patients with JIA (JIA), as it does in adults with rheumatoid arthritis. There are, however, few descriptions concerning systolic and diastolic functions of the left ventricle (LV) in children with JIA. QT dispersion (QTd) is simple noninvasive arrhythmogenic marker that can be used to assess homogeneity of cardiac repolarization and which has not been studied in JIA patients before. A recent study found that rheumatoid arthritis patients had an abnormally longer QTd and corrected QT (cQTd) dispersion, markers for ventricular arrhythmogenicity. This study assessed QTd and cQTd and their relation with systolic and diastolic function of the LV in a group of children with JIA. We performed electrocardiography and Doppler echocardiography on patients and controls. Maximum QT (QTmax), minimum QT (QTmin), QTd, corrected QT, maximum corrected QT (cQTmax), minimum corrected QT (cQTmin) and cQTd intervals were measured from standard 12-lead electrocardiography. No statistically significant differences were found between the groups in QTd and cQTd. Among the diastolic parameters, increased late flow velocity, decreased early flow velocity and prolonged isovolumic relaxation time reflected an abnormal relaxation form of diastolic dysfunction. During 12 months of follow-up, no ventricular arrhythmias were documented in either group.

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey

    Bülent Koca

  2. Department of Pediatric Rheumatology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey

    Özgür Kasapçopur

  3. Department of Pediatric Cardiology, Vivo Medical Center, Istanbul, Turkey

    Süleyman Bakari

  4. Department of Pediatrics, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey

    Emre Çelik

  5. Department of Biostatistics, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey

    Özden Calay

Authors
  1. Bülent Koca
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  2. Özgür Kasapçopur
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  3. Süleyman Bakari
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  4. Emre Çelik
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  5. Özden Calay
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Correspondence to Bülent Koca.

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Koca, B., Kasapçopur, Ö., Bakari, S. et al. QT dispersion and cardiac involvement in patients with juvenile idiopathic arthritis. Rheumatol Int 32, 3137–3142 (2012). https://doi.org/10.1007/s00296-011-2144-z

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  • DOI: https://doi.org/10.1007/s00296-011-2144-z

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