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Evidence-based, interdisciplinary guidelines for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis

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Abstract

Uveitis in juvenile idiopathic arthritis (JIA) is frequently associated with the development of complications and visual loss. Topical corticosteroids are the first-choice therapy, and immunosuppression is commonly used. However, treatment has not been standardized. Representatives from the German Ophthalmological Society, Society for Childhood and Adolescent Rheumatology, and the German Society for Rheumatology reached consensus on a standardized treatment strategy according to disease severity in the individual patient. The recommendations were based on a systematic literature analysis in MEDLINE and consensus expert meetings. Evidence and recommendations were graded, and an algorithm for anti-inflammatory treatment and final statements confirmed in a Delphi method. An interdisciplinary, evidence-based treatment guideline for JIA uveitis is presented.

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Muenster, Germany

    A. Heiligenhaus & C. Schumacher

  2. German Ophthalmological Society, Augenabteilung, Uveitiszentrum, St. Franziskus Hospital, Münster, Germany

    A. Heiligenhaus & C. Schumacher

  3. Society for Childhood and Adolescent Rheumatology, Deutsches Zentrum für Kinder- und Jugendrheumatologie, Garmisch Partenkirchen, Germany

    H. Michels

  4. Working group of the Scientific Medical Specialty Societies, Marburg, Germany

    I. Kopp

  5. Society for Childhood and Adolescent Rheumatology, Universitäts Kinderklinik, Essen, Germany

    U. Neudorf

  6. Society for Childhood and Adolescent Rheumatology, HELIOS Klinikum Krefeld, Zentrum für Kinder- und Jugendmedizin, Krefeld, Germany

    T. Niehues

  7. Parents’ Association for Children with Uveitis and Their Families, Frankfurt, Germany

    H. Baus

  8. German Ophthalmological Society, Stadtspital Triemli, Augenklinik, Zürich, Switzerland

    M. Becker

  9. Professional Association of Ophthalmologists, Augenarztpraxis, Aachen, Germany

    B. Bertram

  10. Society for Childhood and Adolescent Rheumatology, Olgahospital, Klinik für Kinder- und Jugendmedizin, Pädiatrie, Stuttgart, Germany

    G. Dannecker

  11. German Ophthalmological Society, Universitäts-Augenklinik, Tübingen, Germany

    C. Deuter & M. Zierhut

  12. Society for Childhood and Adolescent Rheumatology, Hamburger Zentrum für Kinder- und Jugendrheumatologie, Klinikum Eilbeck, Hamburg, Germany

    I. Foeldvari

  13. Society for Childhood and Adolescent Rheumatology, Universitätskinderklinik Münster, Klinik und Poliklinik für Kinder- und Jugendmedizin, Münster, Germany

    M. Frosch

  14. Society for Childhood and Adolescent Rheumatology, St.-Josefs-Stift, Sendenhorst, Kinder- und Jugendrheumatologie, Sendenhorst, Germany

    G. Ganser

  15. German Society for Rheumatology, Akademie für Manuelle Therapie, Münster, Germany

    M. Gaubitz

  16. Parents’ Association for Children with Uveitis and Their Families, Münster, Germany

    G. Gerdes

  17. Society for Childhood and Adolescent Rheumatology, Asklepios Klinik St. Augustin, Zentrum für Kinder- und Jugendmedizin, Sankt Augustin, Germany

    G. Horneff

  18. Psychologischer Dienst, St. Josef-Stift, Sendenhorst, Kinder- und Jugendrheumatologie, Sendenhorst, Germany

    A. Illhardt

  19. German Ophthalmological Society, Universitäts-Augenklinik, Heidelberg, Germany

    F. Mackensen

  20. Society for Childhood and Adolescent Rheumatology, Deutsches Rheumaforschungszentrum, Berlin, Germany

    K. Minden

  21. German Ophthalmological Society, Universitätsaugenklinik, Charite, Berlin, Germany

    U. Pleyer

  22. German Society for Rheumatology, Heinrich-Heine-Universität, Klinik, und Poliklinik für Rheumatologie, Düsseldorf, Germany

    M. Schneider

  23. Society for Childhood and Adolescent Rheumatology, Rheinisch-Westfälische Technische Hochschule, Kinder- und Jugendmedizin, Aachen, Germany

    N. Wagner

Authors
  1. A. Heiligenhaus
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  2. H. Michels
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  3. C. Schumacher
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  4. I. Kopp
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  5. U. Neudorf
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  6. T. Niehues
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  7. H. Baus
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  8. M. Becker
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  9. B. Bertram
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  10. G. Dannecker
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  11. C. Deuter
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  12. I. Foeldvari
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  13. M. Frosch
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  14. G. Ganser
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  15. M. Gaubitz
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  16. G. Gerdes
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  17. G. Horneff
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  18. A. Illhardt
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  19. F. Mackensen
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  20. K. Minden
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  21. U. Pleyer
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  22. M. Schneider
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  23. N. Wagner
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  24. M. Zierhut
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Corresponding author

Correspondence to A. Heiligenhaus.

Additional information

Guidelines of the German Ophthalmological Society (DOG) and the Society for Childhood and Adolescent Rheumatology (GKJR) in collaboration with the following professional societies: Working group of the Scientific Medical Specialty Societies (AWMF), Professional Association of Ophthalmologists (BVA), German Society for Rheumatology (DGRh), Parents’ Association for Children with Uveitis and Their Families.

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Heiligenhaus, A., Michels, H., Schumacher, C. et al. Evidence-based, interdisciplinary guidelines for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis. Rheumatol Int 32, 1121–1133 (2012). https://doi.org/10.1007/s00296-011-2126-1

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  • DOI: https://doi.org/10.1007/s00296-011-2126-1

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