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−383 A/C tumor necrosis factor receptor 1 polymorphism and ankylosing spondylitis in Mexicans: a preliminary study

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Abstract

The objective of this study was to evaluate the differences in allele and genotype frequencies of −383 tumor necrosis factor receptor 1 (TNFR1) polymorphism between ankylosing spondylitis (AS) and controls. Mexican Mestizos with AS were matched by gender, age, and ethnicity with healthy controls and compared in allele and genotype frequencies of the −383 TNFR1 polymorphism. Polymorphisms were genotyped using PCR–RFLP. The AA genotype occurred at a higher frequency in the AS group (92%) compared with controls (79%, P = 0.03). A allele was increased in AS (96% vs. 88%, P = 0.015) and was associated with genetic susceptibility for AS (odds ratio = 3.48, 95% CI = 1.23–10.61). This preliminary study is the first assessing the association of the −383 A/C TNFR1 polymorphism with AS, although it has the limitation of a small sample size. These data are of interest for the genetic epidemiology of AS in the Mexican population, requiring further investigation in other countries.

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Acknowledgments

Funding for this project was provided by a grant from the Mexican Institute for Social Security (IMSS), FOFOI/1A/I/040.

Conflict of interest

None.

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Authors and Affiliations

  1. Clinical Epidemiology Research Unit, Section of Musculoskeletal Diseases and Autoimmunity, Hospital de Especialidades Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social (IMSS), Belisario Domínguez No. 1000, Col. Independencia, Guadalajara, Mexico

    Esther Guadalupe Corona-Sanchez, Julia Dolores Sanchez-Hernandez & Jorge Ivan Gamez-Nava

  2. Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Departamento de Biología Molecular y Genómica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, 44340, Guadalajara, México

    Esther Guadalupe Corona-Sanchez, José Francisco Muñoz-Valle, Monica Vazquez-Del Mercado & Heriberto Ontiveros-Mercado

  3. Department of Internal Medicine-Rheumatology, Hospital General Regional 110, IMSS, Avenida Circunvalación Oblatos No. 2208 Col. Oblatos, Guadajara, México

    Laura Gonzalez-Lopez & Alberto Daniel Rocha-Muñoz

  4. Postgraduate Program Public Health, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada No. 950, Col. Independencia, 44340, Guadalajara, México

    Laura Gonzalez-Lopez, Alfredo Celis & Jorge Ivan Gamez-Nava

  5. Unidad de Investigación Enrico Stefani, Centro Universitario de Investigaciones Biomédicas, Avenida 25 de julio No. 965 Col. Villas San Sebastian Colima, Colima, México

    Miguel Huerta & Xochitl Trujillo

  6. Central Laboratory, Hospital General Regional 110, IMSS, Avenida Circunvalación Oblatos No. 2208 Col. Oblatos, Guadajara, México

    Ricardo Ortega-Flores

  7. Salto del Agua 2192, Col. Jardines del Country, 44210, Guadalajara, Jalisco, México

    Jorge Ivan Gamez-Nava

Authors
  1. Esther Guadalupe Corona-Sanchez
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  2. José Francisco Muñoz-Valle
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  3. Laura Gonzalez-Lopez
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  4. Julia Dolores Sanchez-Hernandez
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  5. Monica Vazquez-Del Mercado
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  6. Heriberto Ontiveros-Mercado
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  7. Miguel Huerta
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  8. Xochitl Trujillo
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  9. Alberto Daniel Rocha-Muñoz
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  10. Alfredo Celis
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  11. Ricardo Ortega-Flores
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  12. Jorge Ivan Gamez-Nava
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Corresponding author

Correspondence to Jorge Ivan Gamez-Nava.

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Corona-Sanchez, E.G., Muñoz-Valle, J.F., Gonzalez-Lopez, L. et al. −383 A/C tumor necrosis factor receptor 1 polymorphism and ankylosing spondylitis in Mexicans: a preliminary study. Rheumatol Int 32, 2565–2568 (2012). https://doi.org/10.1007/s00296-011-1997-5

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  • DOI: https://doi.org/10.1007/s00296-011-1997-5

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