Abstract
Herpes simplex virus type 1 (HSV-1), also known as herpes labialis, is the etiologic agent of vesicular lesions of the oral mucosa commonly referred to as “cold sores”. HSV-1 can also cause clinical disease in a wide variety of other anatomic locations including the genitalia, liver, lung, eye, and central nervous system. These infections can be severe, particularly in the setting of immunosuppression, such as inflammatory arthropathy patients on Methotrexate ± biological therapies. Here, we highlight the importance of physician awareness of HSV due to its potential impact for rheumatology patients.
References
Freeman ML, Sheridan BS, Bonneau RH, Hendricks RL (2007) Psychological stress compromises CD8+ T cell control of latent herpes simplex Virus type 1 infections. J Immunol 179(1):322–328
Spruance SL, Overall JC Jr, Kern ER, Krueger GG, Pliam V, Miller W (1977) The natural history of recurrent herpes simplex labialis: implications for antiviral therapy. N Engl J Med 297(2):69–75
Kusne S, Schwartz M, Breinig MK, Dummer JS, Lee RE, Selby R, Starzl TE, Simmons RL, Ho M (1991) Herpes simplex virus hepatitis after solid organ transplantation in adults. J Infect Dis 163(5):1001–1007
Becker W, Naude WD, Kipps A, McKenzie D (1963) Virus studies in disseminated herpes simplex infections: association with malnutrition in children. S Afr Med J, 37–74
Hillard P, Seeds J, Cefalo R (1982) Disseminated herpes simplex in pregnancy: two cases and a review. Obstet Gynecol Surv 37(7):449–453
Westheim AI, Tenser RB, Marks JG Jr (1987) Acyclovir resistance in a patient with chronic mucocutaneous herpes simplex infection. J Am Acad Dermatol 17(5 Pt 2):875–880
Hardy WD (1992) Foscarnet treatment of acyclovir-resistant herpes simplex virus infection in patients with acquired immunodeficiency syndrome: preliminary results of a controlled, randomized, regimen-comparative trial. Am J Med 92(2A):30S–35S
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
O’Connor, M.B., Phelan, M.J. The impact of HSV for inflammatory arthropathy patients. Rheumatol Int 32, 489–490 (2012). https://doi.org/10.1007/s00296-010-1758-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-010-1758-x