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Rheumatology International

, Volume 32, Issue 1, pp 91–96 | Cite as

Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population

  • Kyeong-A Lee
  • So-Young Bang
  • Byung Lae Park
  • Jeong-Hyun Kim
  • Hyoung Doo Shin
  • Sang-Cheol BaeEmail author
Original Article

Abstract

Several studies have investigated the roles of genetic polymorphisms in rheumatoid arthritis (RA). Some of these studies reported that polymorphisms of poly(ADP-ribose) polymerase 1 gene (PARP-1) are linked to rheumatoid arthritis. Poly(ADP-ribose) polymerase is an enzyme involved in DNA repair, genomic stability, apoptosis, gene transcription, proliferation, and autoimmunity. To determine whether genetic polymorphisms of PARP-1 are related to rheumatoid arthritis in a Korean population, six single nucleotide polymorphisms (SNPs), which were selected based on LDs and minor allele frequency (MAF > 0.05) in our previous study, were genotyped in 1,202 patients with rheumatoid arthritis and 979 unrelated healthy controls. As a result, no significant association between the susceptibility to rheumatoid arthritis and PAPR-1 polymorphisms was found. However, in further analysis depending on the radiological severity of rheumatoid arthritis, one PARP-1 polymorphism, rs1805413 (OR = 0.11; 95% CI = 0.02–0.55; P = 0.007; P corr = 0.04), and one haplotype (ht6, OR = 0.11; 95% CI = 0.02–0.55; P = 0.007; P corr = 0.04) were significantly associated with the radiological severity risk of RA in a recessive model. In addition, a recessive model revealed a correlation between one RA haplotype (ht4) and anti-CCP antibody negativity (OR 0.24, 95% CI 0.10–0.63, P = 0.003; P corr = 0.02). Despite a possible association between PARP-1 and the radiological severity of RA, this study found no statistical association between PARP-1 polymorphisms and the susceptibility to rheumatoid arthritis in a Korean population.

Keywords

Rheumatoid arthritis (RA) Poly(ADP-ribose) polymerase (PARP) Polymorphism Susceptibility 

Notes

Acknowledgments

This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A010252).

Supplementary material

296_2010_1589_MOESM1_ESM.docx (16 kb)
Supplementary material 1 (DOCX 15 kb)

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Kyeong-A Lee
    • 1
  • So-Young Bang
    • 1
  • Byung Lae Park
    • 2
  • Jeong-Hyun Kim
    • 3
  • Hyoung Doo Shin
    • 2
    • 3
  • Sang-Cheol Bae
    • 1
    Email author
  1. 1.Department of RheumatologyHanyang University Hospital for Rheumatic DiseasesSeoulSouth Korea
  2. 2.Department of Genetic EpidemiologySNP Genetics, Inc.SeoulKorea
  3. 3.Department of Life ScienceSogang UniversitySeoulRepublic of Korea

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