Rheumatology International

, Volume 32, Issue 10, pp 3261–3263 | Cite as

Bronchocentric granulomatosis in a patient with rheumatoid arthritis

  • Cemal BesEmail author
  • Ali Kılıçgün
  • Fahrettin Talay
  • Fahri Yılmaz
  • Mehmet Soy
Case Report


Bronchocentric granulomatosis is an uncommon entity which has no specific clinical, radiological and immunological features. It is usually diagnosed at morphological examination of biopsy or resected lung material. Aetiology of bronchocentric granulomatosis is unclear. A 49–year-old female patient, who was followed up with diagnosis rheumatoid arthritis in our outpatient clinic, presented with right lobe nodular lesion in chest radiography. Right thoracotomy and wedge resection was performed. Pathological examination revealed bronchocentric granulomatosis. Bronchocentric granulomatosis has been rarely reported in rheumatoid arthritis. This case might be a proof that bronchocentric granulomatosis may be one of the respiratory manifestations of rheumatoid arthritis.


Bronchocentric granulomatosis Rheumatoid arthritis 


  1. 1.
    Liebow AA (1973) The J. Burns Amberson lecture-pulmonary angiitis and granulomatosis. Am Rev Respir Dis 108:1–18PubMedGoogle Scholar
  2. 2.
    Myers JL (1989) Bronchocentric granulomatosis. Disease or diagnosis? Chest 96(1):92–95CrossRefGoogle Scholar
  3. 3.
    Katzenstein AL, Liebow AA, Friedman PJ (1975) State of the art: bronchocentric granulomatosis, mucoid impaction and hypersensitivity reactions to fungi. Am Rev Respir Dis 111:497–537PubMedGoogle Scholar
  4. 4.
    Bonafede RP, Benatar SR (1987) Bronchocentric granulomatosis and rheumatoid arthritis. Br J Dis Chest 81(2):197–201PubMedCrossRefGoogle Scholar
  5. 5.
    Hellems SO, Kanner RE, Renzetti AD Jr (1983) Bronchocentric granulomatosis associated with rheumatoid arthritis. Chest 83(5):831–832PubMedCrossRefGoogle Scholar
  6. 6.
    Fishman JA (2002) Fungal infections of the lungs. In: Fishman AP (ed) Manual of pulmonary diseases and disorders, 3rd edn. McGraw-Hill Medical Pub, USA, p 831Google Scholar
  7. 7.
    Popper HH (1988) Bronchocentric granulomatosis. In: Dail DH, Hammer SP (eds) Pulmonary pathology, 1st edn. Springer, New York, pp 312–314Google Scholar
  8. 8.
    Ward S, Heyneman LE, Flint JD et al (2000) Bronchocentric granulomatosis: computed tomografic findings in five patients. Clin Radiol 55:296–300PubMedCrossRefGoogle Scholar
  9. 9.
    van der Klooster JM, Nurmohamed LA, van Kaam NA (2004) Bronchocentric granulomatosis associated with influenza—A virus infection. Respiration 71(4):412–416PubMedCrossRefGoogle Scholar
  10. 10.
    Ishikawa S, Yano S, Touge H, Tokuda Y, Kobayashi K, Ikeda T et al (2007) A case of bronchocentric granulomatosis associated with Aspergillus that was difficult to differentiate from lung cancer. Nihon Kokyuki Gakkai Zasshi 45(11):856–860PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Cemal Bes
    • 1
    Email author
  • Ali Kılıçgün
    • 2
  • Fahrettin Talay
    • 3
  • Fahri Yılmaz
    • 4
  • Mehmet Soy
    • 1
  1. 1.Department of RheumatologyAbant Izzet Baysal University Medical SchoolBoluTurkey
  2. 2.Department of Thoracic SurgeryAbant Izzet Baysal University Medical SchoolBoluTurkey
  3. 3.Department of Chest DiseaseAbant Izzet Baysal University Medical SchoolBoluTurkey
  4. 4.Department of PathologyAbant Izzet Baysal University Medical SchoolBoluTurkey

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