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Etanercept induced organizing pneumonia in a patient with rheumatoid arthritis

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TNF inhibitors are being used in a rapidly expanding number of rheumatoid arthritis (RA) patients due to their effectiveness and acceptable safety profiles. To date, concerns regarding the adverse effects of TNF inhibitors have focused on infections, hematologic malignancies, and demyelinating disorders. Recently, the development of autoantibodies and other autoimmunity has been increasingly reported. Here, we describe a 36-year-old RA patient in whom organizing pneumonia and systemic lupus erythematosus were detected during etanercept treatment.

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  1. Moreland LW, Weinblatt ME, Keystone EC et al (2006) Etanercept treatment in adults with established rheumatoid arthritis: 7 years of clinical experience. J Rheumatol 33:854–861

    PubMed  CAS  Google Scholar 

  2. Wolfe F, Michaud K (2004) Lymphoma in rheumatoid arthritis: the effect of methotrexate and anti-tumor necrosis factor therapy in 18,572 patients. Arthritis Rheum 50:1740–1751

    Article  PubMed  CAS  Google Scholar 

  3. Mohan N, Edwards ET, Cupps TR et al (2001) Demyelination occurring during anti-tumor necrosis factor alpha therapy for inflammatory arthritides. Arthritis Rheum 44:2862–2869

    Article  PubMed  CAS  Google Scholar 

  4. Ramos-Casals M, Brito-Zeron P et al (2008) Autoimmune diseases induced by TNF-targeted therapies. Best Pract Res Clin Rheumatol 22:847–861

    Article  PubMed  CAS  Google Scholar 

  5. Caramaschi P, Biasi D, Colombatti M et al (2006) Anti-TNF alpha therapy in rheumatoid arthritis and autoimmunity. Rheumatol Int 26:209–214

    Article  PubMed  CAS  Google Scholar 

  6. Moreland LW, Schiff MH, Baumgartner SW et al (1999) Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann Intern Med 130:478–486

    PubMed  CAS  Google Scholar 

  7. Schlesinger C, Koss MN (2005) The organizing pneumonias: an update and review. Curr Opin Pulm Med 11:422–430

    Article  PubMed  Google Scholar 

  8. Cordier JF (2006) Cryptogenic organising pneumonia. Eur Respir J 28:422–446

    Article  PubMed  Google Scholar 

  9. Mori S, Cho I, Koga Y, Sugimoto M (2008) A simultaneous onset of organizing pneumonia and rheumatoid arthritis, along with a review of the literature. Mod Rheumatol 18:60–66

    Article  PubMed  Google Scholar 

  10. Kajiya T, Kuroda A, Hokonohara D, Tei C (2006) Radiographic appearance of bronchiolitis obliterans organizing pneumonia (BOOP) developing during Bucillamine treatment for rheumatoid arthritis. Am J Med Sci 332:39–42

    Article  PubMed  Google Scholar 

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Correspondence to Yoon-Kyoung Sung.

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Cho, SK., Oh, I.H., Park, C.K. et al. Etanercept induced organizing pneumonia in a patient with rheumatoid arthritis. Rheumatol Int 32, 1055–1057 (2012).

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