Rheumatology International

, Volume 30, Issue 12, pp 1565–1570 | Cite as

Low prevalence of hepatitis B virus infection in patients with systemic lupus erythematosus in southern China

  • Jijun Zhao
  • Minli Qiu
  • Meirong Li
  • Caisheng LuEmail author
  • Jieruo Gu
Original Article


To investigate the prevalence of hepatitis B virus (HBV) infection in systemic lupus erythematosus (SLE) patients in southern China, SLE inpatients were retrospectively investigated for their HBV infection rate. Fifteen SLE patients positive for hepatitis B surface antigen (HBsAg) were followed up. Furthermore, serum interferon (IFN)-α levels among SLE patients were detected by ELISA. Results showed estimated HBsAg-positive rate was 10.74% in general population. The HBsAg-positive rate was lower in SLE patients compared with controls (2.33 vs. 9.57%, P < 0.01). Interestingly, 13 out of 15 SLE patients converted from HBsAg positive to HBV surface antibody (HBsAb) positive even under glucocorticoid therapy. In addition, we found significantly increased IFN-α levels in SLE patients.The prevalence of HBV infection in SLE patients was lower than that in sex- and age-matched non-SLE controls in southern China. The characteristic IFN signatures in SLE may favor the subsequent clearance of HBV.


Systemic lupus erythematosus Hepatitis B virus Prevalence Interferons 



This study was supported by Grant no. 30571736/C0302050301 from the National Natural Science Foundation of China (NSFC) and Science and Technology Planning Project of Guangdong Province, China (No. 2006B35601003)


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Jijun Zhao
    • 1
  • Minli Qiu
    • 1
  • Meirong Li
    • 1
  • Caisheng Lu
    • 1
    Email author
  • Jieruo Gu
    • 1
  1. 1.Department of Rheumatology, Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina

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