Rheumatology International

, Volume 30, Issue 12, pp 1661–1663 | Cite as

Periodic fever responds to vitamin B12 treatment

  • Sody Naimer
  • Ilia VolkovEmail author
Case Report


Periodic fever of childhood is a group of diseases that cause repeated febrile illnesses with various associated symptoms. In our article, we present the case of a 6-year-old girl with unusual appearance of periodic fever syndrome. Our patient suffered from repeated episodes of high fever from the age of 2 years old. Each episode usually lasted 24–48 h, the interval between events was 1–3 weeks long. During high fever episodes the child usually felt well, without associated accompanying complaints. As a rule, the physical examination did not reveal any pathologic finding explaining the fever. During the 4 years of follow-up the patient sustained treatment attempts with prednisone for a number of months and half a year with colchicine without any response. We considered treatment with sublingual tablets of vitamin B12 (VIT B12). Beyond all expectation, we witnessed complete resolution of attacks during the first 2 months following treatment. After a long episode-free period, the parents withheld the treatment on their own accord, and in a short time the disease recurred. We advised to renew the treatment with VIT B12, and during approximately half year of follow-up there were no recurrences of periodic fever. Conclusion: we believe that our observation raises interest in systematic evaluation of the therapeutic role of VIT B12 as a treatment option for disorders of the periodic fever spectrum.


Periodic fever Familial Mediterranean fever PFAFA Vitamin B12 



The authors thank the staff of Siaal Research Center for Family Medicine and Primary Care for assistance with preparation of the manuscript.

Conflict of interest statement

The authors indicate that they do not have any conflicts of interest.


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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  1. 1.Department of Family Medicine, Siaal Research Center for Family Medicine and Primary Care, Faculty of Health SciencesBen-Gurion University of the Negev Beer-ShevaBeershebaIsrael
  2. 2.Clalit Health ServicesBeershebaIsrael

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