Abstract
Intravenous immunoglobulin (IVIg) is emerging as the mainstay in the treatment of many autoimmune diseases, including systemic lupus erythematosus. IVIg has been found to be beneficial in myocarditis due to dermatomyositis/polymyositis, Kawasaki disease, and viral myocarditis in children. We report an 18-year-old man of active lupus with worsening cardiac systolic function who did not respond to pulse methylprednisolone and cyclophosphamide, but subsequently showed an improvement in his cardiac function after IVIg administration.
References
Moder KG, Miller TD, Tazelaar HD (1999) Cardiac involvement in systemic lupus erythematosus. Mayo Clin Proc 74:275–284
Borenstein DG, Fye WB, Arnett FC, Stevens MB (1978) The myocarditis of systemic lupus erythematosus: association with myositis. Ann Intern Med 89:619–624
Routray SN, Mishra TK, Patnaik UK, Behera M (2004) Myocarditis as an initial manifestation of systemic lupus erythematosus. J Assoc Physicians India 52:673–674
Meier WP, Gordon DS, Howard RF, Saleh MN, Miller SB, Lieberman JD, Woodlee PM (1990) Intravenous immunoglobulin therapy in systemic lupus erythematosus associated-thrombocytopenia. Arthritis Rheum 33:1233–1239
Monova D, Belovezhdov N, Altunkova I, Monov S (2002) Intravenous immunoglobulin G in the treatment of patients with chronic glomerulonephritis: clinical experience lasting 15 years. Nephron 90:262–266
Ravetch JV, Bolland S (2001) IgG Fc receptors. Annu Rev Immunol 19:275–290
Sherer Y, Levy Y, Fabrizzi F, Shoenfeld Y (1999) Immunomodulation of various autoimmune diseases by intravenous immunoglobulin. Drugs Today (Barc) 35:513–518
Yoshikawa H, Nomura Y, Masuda K, Hazeki D, Yotsumoto K, Arata M et al (2006) Four cases of Kawasaki syndrome complicated with myocarditis. Circ J 70:202–205
Drucker NA, Colan SD, Lewis AB, Beiser AS, Wessel DL, Takahashi M et al (1994) Gamma-globulin treatment of acute myocarditis in the pediatric population. Circulation 89:252–257
Seite Jean-François, Shoenfeld Yehuda, Youinou Pierre, Hillion Sophie (2008) What is the contents of the magic draft IVIg? Autoimmun Rev 7:435–439
Sherer Y, Levy Y, Shoenfeld Y (1999) Marked improvement of severe cardiac dysfunction after one course of intravenous immunoglobulin in a patient with systemic lupus erythematosus. Clin Rheumatol 18:238–240
Disla E, Rhim HR, Reddy A, Ramaprasad S, Taranta A (1993) Reversible cardiogenic shock in a patient with lupus myocarditis. J Rheumatol 20:2174
Micheloud D, Calderón M, Caparrros M, D’Cruz DP (2007) Intravenous immunoglobulin therapy in severe lupus myocarditis: good outcome in three patients. Ann Rheum Dis 66:986–987
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Suri, V., Varma, S., Joshi, K. et al. Lupus myocarditis: marked improvement in cardiac function after intravenous immunoglobulin therapy. Rheumatol Int 30, 1503–1505 (2010). https://doi.org/10.1007/s00296-009-1098-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-009-1098-x