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Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis

Rheumatology International volume 30, pages 731–737 (2010)Cite this article

Abstract

Adipose tissue is regarded as an active metabolic and endocrine organ producing adipokines. The purpose of the study was to evaluate adiponectin and leptin concentrations in rheumatoid arthritis (RA) patients (pts) in relation to disease duration and activity. The study group consisted of 80 RA pts. Serum adiponectin and leptin concentrations remained within normal ranges. Adiponectin concentration correlated positively both with the age and disease duration. Both adipokines levels correlated negatively with glomerular filtration rate. There were significant positive correlations between adipokines’ concentrations and lipid profile components (between adiponectin and HDL-cholesterol, leptin and total cholesterol and LDL-cholesterol). In pts with long-standing RA, there was a negative correlation between adiponectin and numbers of tender, swollen joints and a positive relationship between leptin level and DAS28. The results confirm adipokines’ involvement in the process of inflammation and atherosclerosis: protective and antiinflammatory adiponectin effect and proatherogenic and proinflammatory leptin function.

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Fig. 1

Abbreviations

RA:

Rheumatoid arthritis

CVD:

Cardiovascular disease

CAD:

Coronary artery disease

CHF:

Chronic heart failure

OA:

Osteoarthritis

BCM:

Body cell mass

DAS28:

Disease activity 28 joints score

BMI:

Body mass index

TSF:

Tricipital skin fold

TNF-α:

Tumor necrosis factor-α

IL-1β:

Interleukin-1β

MMP-1:

Metalloproteinase-1

WAT:

White adipose tissue

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Conflict of interest statement

The authors declare that they have no competing interests.

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Affiliations

  1. Department of Rheumatology and Connective Tissue Diseases, Medical University of Lublin, ul. Jaczewskiego 8, 20-950, Lublin, Poland

    Bożena Targońska-Stępniak, Magdalena Dryglewska & Maria Majdan

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  1. Bożena Targońska-Stępniak
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  2. Magdalena Dryglewska
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  3. Maria Majdan
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Correspondence to Bożena Targońska-Stępniak.

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Targońska-Stępniak, B., Dryglewska, M. & Majdan, M. Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol Int 30, 731–737 (2010). https://doi.org/10.1007/s00296-009-1053-x

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  • DOI: https://doi.org/10.1007/s00296-009-1053-x

Keywords

  • Rheumatoid Arthritis
  • White Adipose Tissue
  • Adiponectin Level
  • Serum Adiponectin
  • Adiponectin Concentration