Abstract
The objective of this study is to investigate rheumatologic manifestations of hepatitis B and C and their relation with viral load and degree of hepatic fibrosis. Thirty-six HBV and 36 HBV patients were included. Liver biopsy was performed for all participants. We detected arthralgia 53–50%, myalgia 58–61% and fatigue 64–81% in HBV and HCV groups in order. All manifestations did not differ between groups significantly. Pain intensity was higher in HCV group (P = 0.023). Artralgia is associated with viral load of the patients in both groups (P = 0.000 and P = 0.001). Viral load and fatique are correlated in both groups (P = 0.000 and P = 0.001). There is a considerable relation between inflammation and artralgia (P = 0.000) and myalgia (P = 0.033). We conclude that rheumatologic manifestations are common both in HBV and HCV and related with viral load and fibrosis.
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References
Nissen MJ, Fontanges E, Allam Y, Zoulim F, Trépo C, Miossec P (2005) Rheumatological manifestations of hepatitis C: incidence in a rheumatology and non-rheumatology setting and the effect of methotrexate and interferon. Rheumatology (Oxford) 44:1016–1020. doi:10.1093/rheumatology/keh668
Csepregi A, Rojkovich B, Nemesánszky E, Poór G, Héjjas M, Horányi M (2000) Chronic seropositive polyarthritis associated with hepatitis B virus-induced chronic liver disease: a sequel of virus persistence. Arthritis Rheum 43:232–233. doi:10.1002/1529-0131(200001)43:1<232::AID-ANR28>3.0.CO;2-O
Mariette X (2003) Hepatitis C virus, arthritides, arthromyalgia. Joint Bone Spine 70:246–247. doi:10.1016/S1297-319X(03)00071-X
Lormeau C, Falgarone G, Roulot D, Boissier MC (2006) Rheumatologic manifestations of chronic hepatitis C infection. Joint Bone Spine 73:633–638. doi:10.1016/j.jbspin.2006.05.005
Vassilopoulos D, Calabrese LH (2005) Extrahepatic immunological complications of hepatitis C virus infection. AIDS 19(Suppl 3):S123–S127. doi:10.1097/01.aids.0000192080.56808.38
Rosner I, Rozenbaum M, Toubi E, Kessel A, Naschitz JE, Zuckerman E (2004) The case for hepatitis C arthritis. Semin Arthritis Rheum 33:375–387. doi:10.1016/j.semarthrit.2003.12.006
Cacoub P, Ratziu V, Myers RP, Ghillani P, Piette JC, Moussalli J, Poynard T, Multivirc Group (2002) Impact of treatment on extra hepatic manifestations in patients with chronic hepatitis C. J Hepatol 36:812–818. doi:10.1016/S0168-8278(02)00067-3
Adak B, Tekeoğlu I, Ediz L, Budancamanak M, Yazgan T, Karahocagil K, Demirel A (2005) Fibromyalgia frequency in hepatitis B carriers. J Clin Rheumatol 11:157–159. doi:10.1097/01.rhu.0000165291.91623.5c
Ngo Y, Benhamou Y, Thibault V, Ingiliz P, Munteanu M, Lebray P et al (2008) An accurate definition of the status of inactive hepatitis B virus carrier by a combination of biomarkers (FibroTest-ActiTest) and viral load. PLoS ONE 3:e2573. doi:10.1371/journal.pone.0002573
Jessner W, Watkins-Riedel T, Formann E, Steindl-Munda P, Ferenci P (2002) Hepatitis C viral dynamics: basic concept and clinical significance. J Clin Virol 25(Suppl 3):S31–S39. doi:10.1016/S1386-6532(02)00194-4
Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J (1981) Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431–435. doi:10.1002/hep.1840010511
Von Korff M, Ormel J, Keefe FJ, Dworkin SF (1992) Grading the severity of chronic pain. Pain 50:133–149. doi:10.1016/0304-3959(92)90154-4
Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30:473–483. doi:10.1097/00005650-199206000-00002
Han SH (2004) Extrahepatic manifestations of chronic hepatitis B. Clin Liver Dis 8:403–418. doi:10.1016/j.cld.2004.02.003
Ngo Y, Munteanu M, Messous D, Charlotte F, Imbert-Bismut F, Thabut D et al (2006) A prospective analysis of the prognostic value of biomarkers (FibroTest) in patients with chronic hepatitis C. Clin Chem 52:1887–1896. doi:10.1373/clinchem.2006.070961
Cacoub P, Renou C, Rosenthal E, Cohen P, Loury I, Loustaud-Ratti V et al (2000) Extrahepatic manifestations associated with hepatitis C virus infection. A prospective multicenter study of 321 patients. The GERMIVIC. Groupe d’Etude et de Recherche en Medecine Interne et Maladies Infectieuses sur le Virus de l’Hepatite C. Medicine (Baltimore) 79:47–56. doi:10.1097/00005792-200001000-00005
Poynard T, Cacoub P, Ratziu V, Myers RP, Dezailles MH, Mercadier A, Ghillani P, Charlotte F, Piette JC, Moussalli J, Multivirc group (2002) Fatigue in patients with chronic hepatitis C. J Viral Hepat 9:295–303. doi:10.1046/j.1365-2893.2002.00364.x
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Aydeniz, A., Namiduru, M., Karaoglan, I. et al. Rheumatic manifestations of hepatitis B and C and their association with viral load and fibrosis of the liver. Rheumatol Int 30, 515–517 (2010). https://doi.org/10.1007/s00296-009-1010-8
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DOI: https://doi.org/10.1007/s00296-009-1010-8