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Identification of candidate genes for susceptibility to reactive arthritis

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Abstract

This study was undertaken to evaluate the gene expression profile in monocytes from three patients with reactive arthritis (ReA) in remission in order to identify candidate genes accounting for a potential susceptibility to ReA. Gene expression analyses revealed eight differentially expressed mRNA transcripts in monocytes of ReA patients. The major part of genes encoded cytokines, growth factors and chemokines. There was a remarkably high proportion of proangiogenic factors, in particular IP10, ENA-78, and IL-8 accounting for a genetically determined susceptibility to ReA at the host cell level.

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References

  1. Granfors K, Merilahti-Palo R, Luukainen R et al (1998) Persistence of Yersinia antigens in peripheral blood cells from patients with Yersinia enterocolitica O:3 infection with or without reactive arthritis. Arthritis Rheum 41:855–862. doi:10.1002/1529-0131(199805)41:5<855::AID-ART12>3.0.CO;2-J

    Article  PubMed  CAS  Google Scholar 

  2. Rahman MU, Cheema MA, Schumacher HR et al (1992) Molecular evidence for the presence of chlamydia in the synovium of patients with Reiter’s syndrome. Arthritis Rheum 35:521–529. doi:10.1002/art.1780350506

    Article  PubMed  CAS  Google Scholar 

  3. Rihl M, Köhler L, Klos A, Zeidler H (2006) Persistent infection of Chlamydia in reactive arthritis. Ann Rheum Dis 65:281–284. doi:10.1136/ard.2005.044966

    Article  PubMed  CAS  Google Scholar 

  4. Dougados M, van der Linden S, Juhlin R et al (1991) The European Spondylarthropathy Study Group preliminary criteria for the classification of spondylarthropathy. Arthritis Rheum 34:1218–1230. doi:10.1002/art.1780341003

    Article  PubMed  CAS  Google Scholar 

  5. Sieper J, Rudwaleit M, Braun J, van der Heijde D (2002) Diagnosing reactive arthritis: role of clinical setting in the value of serologic and microbiologic assays. Arthritis Rheum 46:319–327. doi:10.1002/art.504

    Article  PubMed  Google Scholar 

  6. Schrader S, Klos A, Hess S et al (2007) Expression of inflammatory host genes in Chlamydia trachomatis-infected human monocytes. Arthritis Res Ther 9:R54. doi:10.1186/ar2209

    Article  PubMed  Google Scholar 

  7. Gu J, Rihl M, Märker-Hermann E et al (2002) Clues to pathogenesis of spondyloarthropathy derived from synovial fluid mononuclear cell gene expression profiles. J Rheumatol 29:2159–2164

    PubMed  CAS  Google Scholar 

  8. Rihl M, Baeten D, Seta N et al (2004) Technical validation of cDNA-based microarray as screening technique to identify candidate genes in synovial tissue biopsies from spondyloarthropathy patients. Ann Rheum Dis 63:498–507. doi:10.1136/ard.2003.008052

    Article  PubMed  CAS  Google Scholar 

  9. Rihl M, Gu J, Baeten D, Märker-Hermann E et al (2004) Alpha beta but not gamma delta T cell clones in synovial fluids of patients with reactive arthritis show active transcription of tumour necrosis factor alpha and interferon gamma. Ann Rheum Dis 63:1673–1676. doi:10.1136/ard.2003.018192

    Article  PubMed  CAS  Google Scholar 

  10. Koch AE, Kunkel SL, Harlow LA et al (1994) Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis. J Clin Invest 94:1012–1018. doi:10.1172/JCI117414

    Article  PubMed  CAS  Google Scholar 

  11. Gabay C (2006) Interleukin-6 and chronic inflammation. Arthritis Res Ther 8(Suppl 2):S3. doi:10.1186/ar1917

    Article  PubMed  Google Scholar 

  12. O’Sullivan BJ, Thomas HE, Pai S et al (2006) IL-1 beta breaks tolerance through expansion of CD25+ effector T cells. J Immunol 176:7278–7287

    PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by the Deutsche Forschungsgemeinschaft DFG (RI 1119/1-1 and KU1182/1-and 1-3) and the Competence Network Rheumatology (KNR/BMBF, Berlin).

Conflict of interest statements

We, the authors of the present study, herewith declare that they have no financial, non-financial, or any other competing interests that that may involve a conflict of interest. We also declare that this manuscript or any part of it is currently not submitted or has not been published elsewhere in other than abstract form. All authors have read the manuscript and approved its current content.

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Authors and Affiliations

  1. Clinic for Immunology and Rheumatology, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Markus Rihl, Christian Barthel & Reinhold E. Schmidt

  2. Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Andreas Klos

  3. Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Markus Rihl & Paul P. Tak

  4. Rheumatologikum Hannover, Rathenaustr. 13/14, 30159, Hannover, Germany

    Henning Zeidler

  5. Department of Rheumatology, Rotes Kreuz Krankenhaus, St.-Pauli-Deich 24, 29199, Bremen, Germany

    Jens G. Kuipers

Authors
  1. Markus Rihl
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  2. Christian Barthel
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  3. Andreas Klos
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  4. Reinhold E. Schmidt
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  5. Paul P. Tak
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  6. Henning Zeidler
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  7. Jens G. Kuipers
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Corresponding author

Correspondence to Markus Rihl.

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Rihl, M., Barthel, C., Klos, A. et al. Identification of candidate genes for susceptibility to reactive arthritis. Rheumatol Int 29, 1519–1522 (2009). https://doi.org/10.1007/s00296-009-0992-6

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  • DOI: https://doi.org/10.1007/s00296-009-0992-6

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