Skip to main content

Advertisement

Log in

Spondylodiscitis due to an emergent fungal pathogen: Blastoschizomyces capitatus, a case report and review of the literature

  • Short Communication
  • Published:
Rheumatology International Aims and scope Submit manuscript

Abstract

The study includes a case report and a literature review. The main objective of this study is to present a case of spondylodiscitis due to a fungal pathogen, Blastoschizomyces capitatus and to review the published literature on this emergent fungus in etiology of spondylodiscitis, and osteomyelitis. Osteoarticular involvement due to B. capitatus has been reported in six cases, and vertebral involvement has been seen in five of them. All of these cases had underlying malignancy. Infection is usually advanced at presentation. Case notes and online databases were reviewed. Organism was isolated from bone material in all of the cases and antibiotic treatment by antifungal agents cured the infection. We present another case of infectious spondylodiscitis due to B. capitaus, which is reported first in Turkey and tried to attract attendance to this emergent fungal pathogen as an etiologic agent of spine infections in cancer patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

References

  1. D'Antonio D, Piccolomini R, Fioritoni G, Iacone A, Betti S, Fazii P, Mazzoni A (1994) Osteomyelitis and intervertebral discitis caused by Blastoschizomyces capitatus in a patient with acute leukemia. J Clin Microbiol 32(1):224–227

    PubMed  Google Scholar 

  2. Groll AH, Walsh TJ (2001) Uncommon opportunistic fungi: new nosocomial threats. Clin Microbiol Infect 7(Suppl 2):8–24. doi:10.1111/j.1469-0691.2001.tb00005.x

    Article  PubMed  CAS  Google Scholar 

  3. Ortiz AM, Sanz-Rodriguez C, Culebras J et al (1998) Multiple spondylodiscitis caused by Blastoschizomyces capitatus in an allogeneic bone marrow transplantation recipient. J Rheumatol 25:2276–2278

    PubMed  CAS  Google Scholar 

  4. Cheung MY, Chiu NC, Chen SH et al (1999) Mandibular osteomyelitis caused by Blastoschizomyces capitatus in a child with acute myelogenous leukemia. J Formos Med Assoc 98:787–789

    PubMed  CAS  Google Scholar 

  5. Martino R, Salavert M, Parody R et al (2004) Blastoschizomyces capitatus infection in patients with leukemia: report of 26 cases. Clin Infect Dis 38:335–341. doi:10.1086/380643

    Article  PubMed  Google Scholar 

  6. Yoshihara T, Mori K, Nishimura Y et al (2004) Osteocartilaginous involvement in Blastoschizomyces capitatus (Trichosporon capitatum) infection in a bone marrow transplant recipient. Br J Haematol 124:405. doi:10.1046/j.1365-2141.2003.04666.x

    Article  PubMed  Google Scholar 

  7. Mejdoubi M, Huynh A, Danho C, Boot B (2008) Cervical spondylodiscitis caused by Blastoschizomyces capitatus. Infection. doi:10.1007/s15010-007-7081-0

  8. Liu KL, Herbrecht R, Bergerat JP et al (1990) Disseminated Trichosporon capitatum infection in a patient with acute leukemia undergoing bone marrow transplantation. Bone Marrow Transplant 6:219–221

    PubMed  CAS  Google Scholar 

  9. D’Antonio D, Mazzoni A, Iacone A et al (1996) Emergence of fluconazole-resistant strains of Blastoschizomyces capitatus causing nosocomial infections in cancer patients. J Clin Microbiol 34:753–755

    PubMed  Google Scholar 

  10. Martino P, Venditti M, Micozzi A et al (1990) Blastoschizomyces capitatus: an emerging cause of invasive fungal disease in leukemia patients. Rev Infect Dis 12:570–582

    PubMed  CAS  Google Scholar 

  11. Buchta V, Zak P, Kohout A et al (2001) Case report. Disseminated infection of Blastoschizomyces capitatus in a patient with acute myelocytic leukaemia. Mycoses 44:505–512. doi:10.1046/j.1439-0507.2001.00699.x

    Article  PubMed  CAS  Google Scholar 

  12. Polacheck I, Salkin IF, Kitzes-Cohen R et al (1992) Endocarditis caused by Blastoschizomyces capitatus and taxonomic review of the genus. J Clin Microbiol 30:2318–2322

    PubMed  CAS  Google Scholar 

  13. Sanz MA, Lopez F, Martinez ML et al (1996) Disseminated Blastoschizomyces capitatus infection in acute myeloblastic leukaemia. Report of three cases. Support Care Cancer 4:291–293. doi:10.1007/BF01358882

    Article  PubMed  CAS  Google Scholar 

  14. Al-Hedaithy SS (2003) The yeast species causing fungemia at a university hospital in Riyadh, Saudi Arabia, during a 10-year period. Mycoses 40:293–298

    Google Scholar 

  15. Sycova-Mila Z, Sufliarsky J, Trupl J et al (1992) Catheter associated septicemia due to Trichosporon capitatum. J Hosp Infect 22:257–258. doi:10.1016/0195-6701(92)90050-V

    Article  PubMed  CAS  Google Scholar 

  16. Mahul P, Piens MA, Guyotat D et al (1989) Disseminated Geotrichum capitatum infection in a patient with acute myeloid leukemia. Mycoses 32:573–577

    Article  PubMed  CAS  Google Scholar 

  17. Ito T, Ishikawa Y, Fujii R et al (1988) Disseminated Trichosporon capitatum infection in a patient with acute leukemia. Cancer 61:585–588. doi:10.1002/1097-0142(19880201)61:3<585::AID-CNCR2820610327>3.0.CO;2-#

    Article  PubMed  CAS  Google Scholar 

  18. Naficy AB, Murray HW (1990) Isolated meningitis caused by Blastoschizomyces capitatus. J Infect Dis 161:1041

    PubMed  CAS  Google Scholar 

  19. Baird DR, Harris M, Menon R et al (1985) Systemic infection with Trichosporon capitatum in two patients with acute leukaemia. Eur J Clin Microbiol 4:62–64. doi:10.1007/BF02148664

    Article  PubMed  CAS  Google Scholar 

  20. Haupt HM, Merz WG, Beschorner WE et al (1983) Colonization and infection with Trichosporon species in the immunosuppressed host. J Infect Dis 147:199–203

    PubMed  CAS  Google Scholar 

  21. Winston DJ, Balsley GE, Rhodes J et al (1977) Disseminated Trichosporon capitatum infection in an immunosuppressed host. Arch Intern Med 137:1192–1195. doi:10.1001/archinte.137.9.1192

    Article  PubMed  CAS  Google Scholar 

  22. Perez-Sanchez I, Anguita J, Martin-Rabadan P et al (2000) Blastoschizomyces capitatus infection in acute leukemia patients. Leuk Lymphoma 39:209–212

    PubMed  CAS  Google Scholar 

  23. Girmenia C, Micozzi A, Venditti M et al (1991) Fluconazole treatment of Blastoschizomyces capitatus meningitis in an allogeneic bone marrow recipient. Eur J Clin Microbiol Infect Dis 10:752–756. doi:10.1007/BF01972503

    Article  PubMed  CAS  Google Scholar 

  24. Schiemann R, Glasmacher A, Bailly E et al (1998) Geotrichum capitatum septicaemia in neutropenic patients: case report and review of the literature. Mycoses 41:113–116

    Article  PubMed  CAS  Google Scholar 

  25. Amft N, Miadonna A, Viviani MA et al (1996) Disseminated Geotrichum capitatum infection with predominant liver involvement in a patient with non Hodgkin’s lymphoma. Haematologica 81:352–355

    PubMed  CAS  Google Scholar 

  26. Arnold AG, Gribbin B, De Leval M et al (1981) Trichosporon capitatum causing recurrent fungal endocarditis. Thorax 36:478–480. doi:10.1136/thx.36.6.478

    Article  PubMed  CAS  Google Scholar 

  27. Pimentel JD, Baker M, Woodgyer AJ et al (2005) Fatal disseminated Blastoschizomyces capitatus (Geotrichum capitatum) in a patient with relapse of acute lymphoblastic leukaemia. Pathology 37:319–321. doi:10.1080/00313020500169222

    Article  PubMed  Google Scholar 

  28. Christakis G, Perlorentzou S, Aslanidou M et al (2005) Fatal Blastoschizomyces capitatus sepsis in a neutropenic patient with acute myeloid leukemia: first documented case from Greece. Mycoses 48:216–220. doi:10.1111/j.1439-0507.2005.01098.x

    Article  PubMed  CAS  Google Scholar 

  29. Wills TS, Degryse A, Lavina J et al (2004) Blastoschizomyces capitatus pneumonia in an immunocompetent male. South Med J 97:702–704. doi:10.1097/00007611-200407000-00019

    Article  PubMed  Google Scholar 

  30. Gadea I, Cuenca-Estrella M, Prieto E et al (2004) Genotyping and antifungal susceptibility profile of Dipodascus capitatus isolates causing disseminated infection in seven hematological patients of a tertiary hospital. J Clin Microbiol 42:1832–1836. doi:10.1128/JCM.42.4.1832-1836.2004

    Article  PubMed  CAS  Google Scholar 

  31. Girmenia C, Pagano L, Martino B et al (2005) Invasive infections caused by Trichosporon species and Geotrichum capitatum in patients with hematological malignancies: a retrospective multicenter study from Italy and review of the literature. J Clin Microbiol 43:1818–1828. doi:10.1128/JCM.43.4.1818-1828.2005

    Article  PubMed  Google Scholar 

  32. De Maio J, Colman L (2000) The use of adjuvant interferon-gamma therapy for hepatosplenic Blastoschizomyces capitatus infection in a patient with leukemia. Clin Infect Dis 31:822–824. doi:10.1086/314047

    Article  Google Scholar 

  33. Fanci R, Pecile P (2003) Geotrichum capitatum fungemia in a patient with acute myeloid leukemia: case report. J Chemother 15:412–413

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Aygul Dogan Celik.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Celik, A.D., Ozaras, R., Kantarcioglu, S. et al. Spondylodiscitis due to an emergent fungal pathogen: Blastoschizomyces capitatus, a case report and review of the literature. Rheumatol Int 29, 1237–1241 (2009). https://doi.org/10.1007/s00296-009-0928-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00296-009-0928-1

Keywords

Navigation