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IkBα promoter polymorphisms in patients with ankylosing spondylitis

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Abstract

The purpose of this study is to investigate the association of IκBα with the development of ankylosing spondylitis (AS) in Taiwan. One hundred and fifty-four patients with AS and 112 unrelated healthy controls were enrolled in this study. The IκBα-881A/G, -826C/T, -550A/T, -519C/T, and -297C/T polymorphisms were determined by the polymerase chain reaction/restriction fragment length polymorphism method. This study demonstrated that the genotype frequencies of IκBα-826C/T and -826T/T, and allele frequencies of IκBα-826T were significantly higher in the patients with AS than in the controls. We also found that the estimated haplotype frequencies of IκBα-881A -826T -550A -519C -297C and IκBα-881A -826C -550A -519T -297C were significantly increased in the patient with AS in comparison with that of the controls. In contrast, the estimated haplotype frequency of IκBα-881A -826C -550A -519C -297C was significantly decreased in the patients with AS. This study demonstrates that IκBα-826T is associated with the development of AS. Furthermore, the IκBα-881A -826T -550A -519C -297C and IκBα-881A -826C -550A -519T -297C haplotypes are related to susceptibility to AS in Taiwan.

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Acknowledgments

Part of this laboratory work was supported by a grant from CAPCO Cultural and Educational Foundation.

Conflict of interest statement

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Yu-Hung Hung & Jeng-Hsien Yen

  2. Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Zihyou 1st Road, Kaohsiung, 807, Taiwan

    Tsan-Teng Ou, Chia-Hui Lin, Wen-Chan Tsai, Hong-Wen Liu & Jeng-Hsien Yen

  3. Department of Biomedical Science and Environmental Biology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan

    Ruei-Nian Li

  4. Division of General Internal Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    Yu-Chih Lin

  5. Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Jeng-Hsien Yen

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  1. Yu-Hung Hung
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Correspondence to Jeng-Hsien Yen.

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Hung, YH., Ou, TT., Lin, CH. et al. IkBα promoter polymorphisms in patients with ankylosing spondylitis. Rheumatol Int 30, 93–97 (2009). https://doi.org/10.1007/s00296-009-0923-6

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  • DOI: https://doi.org/10.1007/s00296-009-0923-6

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