Abstract
In a previous study, the musculoskeletal affections among kidney recipients (KR) were reported, with 63 KR suffering from joint affections. We sought to determine the prevalence of osteonecrosis (ON) among those KR with joint affections, its distribution among the affected joints, and possible risk predictors. KR were subjected to biochemical, haematological, and hepatitis serology estimations. Radiographic and magnetic resonance imaging were performed. Relevant data were retrieved from Patient Information System. Fourteen KR were suffering from ON, with an incidence of 22.2% in KR with joint affections and 12.0% in the target population of KR. The femoral head was affected in 57.1% and the femoral condyles in 28.6%. Hypocalcaemia was observed in KR with ON. Whether hypocalcaemia is a causative or associative of ON yet remains to be decided in forthcoming studies.
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Mont M, Hungerford DS (1995) Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am 77:459–474
Hawking KM (1976) Avascular necrosis of the bone after renal transplantation. N Engl J Med 294:397
Kart-Köseoglu H, Yücel AE, Isiklar I et al (2003) Joint pain and arthritis in renal transplant recipients and correlation with cyclosporine therapy. Rheumatol Int 23:159–162
Sakai T, Sugano N, Kokado Y et al (2003) Tacrolimus may be associated with lower osteonecrosis rates after renal transplantation. Clin Orthop 415:163–170
Lopez-Ben R, Mikuls TR, Moore DS et al (2004) Incidence of hip osteonecrosis among renal transplantation recipients: a prospective study. Clin Radiol 59:431–438
Atallah AM, Farag SM, Senna MK et al (2008) Musculoskeletal affections among kidney recipients: prevalence and risk predictors. Rheumatol Int 28:1085–1090
Steinberg ME, Hayken GD, Steinberg DR (1995) A quantitative system for staging avascular necrosis. J Bone Joint Surg Br 77:34–41
Lotke PA, Ecker ML (1988) Current concepts review-osteonecrosis of the knee. J Bone joint Surg Am 70:470–473
Mitchell DG, Rao VM, Dalinka MK et al (1987) Femoral head avascular necrosis: correlation of MR imaging, radiographic staging, radionuclide imaging, and clinical findings. Radiography 162:709–715
Kubo T, Yamazoe S, Sugano N et al (1997) Initial MRI findings of non-traumatic osteonecrosis of the femoral head in renal allograft recipients. Magn Reson Imaging 15:1017–1023
Kubo T, Fujioka M, Yamazoe S et al (1998) Relationship between steroid dosage and osteonecrosis of the femoral head after renal transplantation as measured by magnetic resonance imaging. Transplant Proc 30:3039–3040
Hedri H, Cherif M, Zouaghi K et al (2007) Avascular osteonecrosis after renal transplantation. Transplant Proc 39:1036–1038
Kopecky KK, Braunstein EM, Brandt KD et al (1991) Apparent avascular necrosis of the hip: appearance and spontaneous resolution of MR findings in renal allograft recipients. Radiology 179:523–527
Cheng EY, Thongtrangan I, Laorr A et al (2004) Spontaneous resolution of osteonecrosis of the femoral head. J Bone Joint Surg Am 86:2594–2599
Mulliken BD, Renfrew DL, Brand RA et al (1994) The prevalence and natural history of early osteonecrosis (ON) of the femoral head. Iowa Orthop J 14:115–119
Marston SB, Gillingham K, Bailey RF et al (2002) Osteonecrosis of the femoral head after solid organ transplantation. J Bone Joint Surg Am 84:2145–2151
La Porte DM, Mont MA, Mohan V et al (1998) Multifocal osteonecrosis. J Rheumatol 25:1968–1974
Sakai T, Sugano N, Ohzono K (1998) MRI evaluation of steroid- or alcohol-related osteonecrosis of the femoral condyles. Acta Orthop Scand 69:598–602
Collaborative Osteonecrosis Group (1999) Symptomatic multifocal osteonecrosis: a multicenter study. Clin Orthop 369:312–326
Agrawal L (1996) Polyostotic osteonecrosis in a patient with celiac disease. Endocr Pract 2:385–388
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Atallah, A.M., Abou El-Ghar, M.E. & Ghoneim, M.A. Osteonecrosis in kidney recipients: has hypocalcaemia a role?. Rheumatol Int 30, 75–79 (2009). https://doi.org/10.1007/s00296-009-0918-3
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DOI: https://doi.org/10.1007/s00296-009-0918-3