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Sarcoid-like granulomas in common variable immunodeficiency

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Abstract

Common variable immunodeficiency (CVID) is a disorder characterized by hypogammaglobulinemia, poor antibody responses and recurrent bacterial infections. CVID patients have a higher prevalence of autoimmune disease and some of them develop noncaseating granulomas of the lungs, spleen, liver, skin, lymph nodes and eye. We report herein a 5-year-old girl with CVID presented with cutaneous nodules, granulomatous uveitis and oligoarthritis. The lesions, arthritis and uveitis responded well to treatment with the systemic administration of steroid. Different autoimmune diseases could be seen together in children with CVID. These patients require therapeutic cooperation of the immunologists with different specialists, including dermatologists, rheumatologists and ophthalmologists.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Immunology and Allergy, Selcuk University Meram Medical Faculty, Konya, Turkey

    Hasibe Artac & Ismail Reisli

  2. Department of Ophthalmology, Selcuk University Meram Medical Faculty, Konya, Turkey

    Banu Bozkurt

  3. Department of Pediatrics, Pediatric Pathology Unit, Hacettepe University, Ankara, Turkey

    Beril Talim

Authors
  1. Hasibe Artac
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  2. Banu Bozkurt
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  3. Beril Talim
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  4. Ismail Reisli
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Correspondence to Hasibe Artac.

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Artac, H., Bozkurt, B., Talim, B. et al. Sarcoid-like granulomas in common variable immunodeficiency. Rheumatol Int 30, 109–112 (2009). https://doi.org/10.1007/s00296-009-0897-4

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  • DOI: https://doi.org/10.1007/s00296-009-0897-4

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