Abstract
Familial Mediterranean fever (FMF) is a systemic relapsing autoinflammatory disorder occurring in populations originating from the Mediterranean basin, mainly Turks, Levantine Arabs, Sephardic Jews, Druze, and Armenians. The prevalence of FMF shows considerable geographical variation. In Turkey, the prevalence rates were reported as 0.0027–0.25%. This field survey was conducted in different regions to investigate the frequency of FMF in a northern province of Turkey. This study was conducted in 70 areas (12 urban and 58 rural) in the province of Tokat, which is in northern Turkey. The population of Tokat was reported to be 828,000 at the last census in Turkey in 2000, about 530,000 for individuals aged >18 years (http://www.die.gov.tr). Mean age of 1,095 (541 male and 554 female; urban 555 and rural 540) subjects was 41 ± 17 (range 18–95 years). FMF frequency in this study was 1/123 (0.82%, 95 CI: 0.40–1.61). Mean age of patients were 27 years (20–41) and mean age of symptoms were 16.3 years (11–23). In conclusion, the frequency of FMF in this study was 1/123 (0.82%) which was higher than expected. This rate is the highest frequency of FMF reported from Turkey. Further large sample studies are needed to define to true prevalence of FMF in Turkey.
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References
Sohar E, Gafni J, Pras M, Heller H (1967) Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med 43(2):227–253
Ben-Chetrit E, Levy M (1998) Familial Mediterranean fever. Lancet 351:659–664. doi:10.1016/S0140-6736(97)09408-7
Samuels J, Ozen S (2006) Familial Mediterranean fever and the other autoinflammatory syndromes: evaluation of the patient with recurrent fever. Curr Opin Rheumatol 18:108–117. doi:10.1097/01.bor.0000198006.65697.5b
Çobankara V, Fidan G, Turk T, Zencir M, Çolakoglu M, Ozen S (2004) The prevalence of familial Mediterranean fever in the Turkish province of Denizli: a field study with a zero patient design. Clin Exp Rheumatol 22(Suppl. 34):27–30
Ozen S, Karaaslan Y, Ozdemir O, Saatci U, Bakkaloglu A, Koroglu E, Tezcan S (1998) Prevalence of juvenile chronic arthritis and familial Mediterranean fever in Turkey: a field study. J Rheumatol 25:2445–2449
Dinc A, Pay S, Turan M, Simsek I (2000) Prevalence of familial Mediterranean fever in young Turkish men. Clin Exp Rheumatol 18:292 abstract
Onen F, Sumer H, Turkay S, Akyurek O, Tunca M, Ozdogan H (2004) Increased frequency of familial Mediterranean fever in Central Anatolia, Turkey. Clin Exp Rheumatol 22(Suppl 34):31–33
Tunca M, Akar S, Onen F, Ozdogan H, Kasapcopur O, Yalcinkaya F, Tutar E, Ozen S, Topaloglu R, Yilmaz E, Arici M, Bakkaloglu A, Besbas N, Akpolat T, Dinc A, Erken E, Turkish FMF Study Group (2005) Familial Mediterranean fever FMF in Turkey: results of a nationwide multicenter study. Medicine (Baltimore) 84(1):1–11
Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, Migdal A, Padeh S, Pras M (1997) Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 40:1879–1885. doi:10.1002/art.1780401023
Daniels M, Shohat T, Brenner-Ullman A, Shohat M (1995) Familial Mediterranean fever: high gene frequency among the non-Ashkenazic and Ashkenazic Jewish populations in Israel. Am J Med Genet 55:311–314. doi:10.1002/ajmg.1320550313
Seyahi E, Mangan MS, Oktay V, Çevirgen D, Muratyan, Yazici H (2007). İstanbul’da yaşayan Ermeni Toplumunda Ailevi Akdeniz Ateşi ve Behçet Sendromu sıklığı: prevelans çalışması ön sonuçları. Ulusal Romatoloji Kongresi. Sözel sunu No. 0006
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Kisacik, B., Yildirim, B., Tasliyurt, T. et al. Increased frequency of familial Mediterranean fever in northern Turkey: a population-based study. Rheumatol Int 29, 1307–1309 (2009). https://doi.org/10.1007/s00296-009-0849-z
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DOI: https://doi.org/10.1007/s00296-009-0849-z